WE WANT THE FACTS

Where did this science come from? NLM, NIH, CDC, FDA, OXFORD JOURNALS, PUBMED...WHERE YOUR DR GETS HIS INFORMATION. (Besides the sales reps selling the vaccines to him)

NLM.NCBI.NIH.GOV
The United States National Library of Medicine (NLM), operated by the United States federal government, is the world's largest medical library. The NLM is a division of the National Institutes of Health. Its collections include more than seven million books, journals, technical reports, manuscripts, microfilms, photographs, and images on medicine and related sciences including some of the world's oldest and rarest works.

FDA.GOVThe Food and Drug Administration (FDA or USFDA) is an agency of the United States Department of Health and Human Services, one of the United States federal executive departments.

CDC.GOV- Centers for Disease Control and Prevention (CDC) is a United States federal agency under the Department of Health and Human Services.  It works to protect public health and safety by providing information to enhance health decisions, and it promotes health through partnerships with state health departments and other organizations.

Most other links/full text links are to direct online science journals also included in the NLM above. Make an INFORMED decision.

Share

"According to Hippocratic tradition, the safety level of a preventive medicine must be very high, as it is aimed at protecting people against diseases that they may not contract. This paper points out that information on the safety of hepatitis B vaccine (HBV) is biased as compared to classical requirements of evidence-based medicine (EBM), as exemplified by a documented selectivity in the presentation or even publication of available clinical or epidemiological data. Then, a review is made of data suggesting that HBV is remarkable by the frequency, the severity and the variety of its complications, some of them probablyrelated to a mechanism of molecular mimicry leading to demyelinating diseases, and the others reproducing the spectrum of non-hepatic manifestations of natural hepatitis B. To be explained, this unusual spectrum of toxicity requires additional investigations based upon complete release of available data."


http://www.ncbi.nlm.nih.gov/pubmed/15722255

Download Full Study Here 

 

• "Although there is no information regarding the duration of acceptable observation period, 1–3 months may not be long enough for the purpose, considering that it takes 2–6 months for adjuvant oils to induce lupus autoantibodies in mice [8,9,34] and that the oil-induced granulomatous inflammation can last for years."


"An important factor to consider in vaccine-induced autoimmunity is the fact that vaccines contain a microbial component (or other type of antigens) and adjuvant [75]. Differentiating adverse reactions caused by these two factors is often difficult, or it can even be a result of the combination of both. Nevertheless, the microbial components are generally considered responsible for adverse reactions and minimum attention has been paid to the potential effects of the adjuvant component. Molecular mimicry of a microbial antigen in a vaccine and a host tissue self-antigen is often considered important [61]. Immune complexes also may be formed following vaccination [61,76], deposit in vascular endothelium and induce vasculitis. Induction of cytokines or shifting cytokine balance may also play an important role."


http://www.ncbi.nlm.nih.gov/pubmed/15194169
 

"We find that ethylmercury not only inhibits mitochondrial respiration leading to a drop in the steady state membrane potential, but also concurrent with these phenomena increases the formation of superoxide, hydrogen peroxide, and Fenton/Haber-Weiss generated hydroxyl radical. These oxidants increase the levels of cellular aldehyde/ketones. Additionally, we find a five-fold increase in the levels of oxidant damaged mitochondrial DNA bases and increases in the levels of mtDNA nicks and blunt-ended breaks. Highly damaged mitochondria are characterized by having very low membrane potentials, increased superoxide/hydrogen peroxide production, and extensively damaged mtDNA and proteins. These mitochondria appear to have undergone a permeability transition, an observation supported by the five-fold increase in Caspase-3 activity observed after Thimerosal treatment."


http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395253/


“Aluminum is an experimentally demonstrated neurotoxin and the most commonly used vaccine adjuvant. Despite almost 90 years of widespread use of aluminum adjuvants, medical science's understanding about their mechanisms of action is still remarkably poor. There is also a concerning scarcity of data on toxicology and pharmacokinetics of these compounds. In spite of this, the notion that aluminum in vaccines is safe appears to be widely accepted. Experimental research, however, clearly shows that aluminum adjuvants have a potential to induce serious immunological disorders in humans. In particular, aluminum in adjuvant form carries a risk for autoimmunity, long-term brain inflammation and associated neurological complications and may thus have profound and widespread adverse health consequences. In our opinion, the possibility that vaccine benefits may have been overrated and the risk of potential adverse effects underestimated, has not been rigorously evaluated in the medical and scientific community”  

http://www.ncbi.nlm.nih.gov/pubmed/21568886
 

Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration.

“Possible causes of GWS include several of the adjuvants in the anthrax vaccine and others. The most likely culprit appears to be aluminum hydroxide. In an initial series of experiments, we examined the potential toxicity of aluminum hydroxide in male, outbred CD-1 mice injected subcutaneously in two equivalent-to-human doses. After sacrifice, spinal cord and motor cortex samples were examined by immunohistochemistry. Aluminum-treated mice showed significantly increased apoptosis of motor neurons and increases in reactive astrocytes and microglial proliferation within the spinal cord and cortex. Morin stain detected the presence of aluminum in the cytoplasm of motor neurons with some neurons also testing positive for the presence of hyper-phosphorylated tau protein, a pathological hallmark of various neurological diseases, including Alzheimer's disease and frontotemporal dementia. A second series of experiments was conducted on mice injected with six doses of aluminum hydroxide. Behavioural analyses in these mice revealed significant impairments in a number of motor functions as well as diminished spatial memory capacity. The demonstrated neurotoxicity of aluminum hydroxide and its relative ubiquity as an adjuvant suggest that greater scrutiny by the scientific community is warranted.”     


http://www.ncbi.nlm.nih.gov/pubmed/19740540

Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations

"Immune challenges during early development, including those vaccine-induced, can lead to permanent detrimental alterations of the brain and immune function. Experimental evidence also shows that simultaneous administration of as little as two to three immune adjuvants can overcome genetic resistance to autoimmunity. In some developed countries, by the time children are 4 to 6 years old, they will have received a total of 126 antigenic compounds along with high amounts of aluminum (Al) adjuvants through routine vaccinations. According to the US Food and Drug Administration, safety assessments for vaccines have often not included appropriate toxicity studies because vaccines have not been viewed as inherently toxic. Taken together, these observations raise plausible concerns about the overall safety of current childhood vaccination programs. When assessing adjuvant toxicity in children, several key points ought to be considered: (i) infants and children should not be viewed as "small adults" with regard to toxicological risk as their unique physiology makes them much more vulnerable to toxic insults; (ii) in adult humans Al vaccine adjuvants have been linked to a variety of serious autoimmune and inflammatory conditions (i.e., "ASIA"), yet children are regularly exposed to much higher amounts of Al from vaccines than adults; (iii) it is often assumed that peripheral immune responses do not affect brain function. However, it is now clearly established that there is a bidirectional neuro-immune cross-talk that plays crucial roles in immunoregulation as well as brain function. In turn, perturbations of the neuro-immune axis have been demonstrated in many autoimmune diseases encompassed in "ASIA" and are thought to be driven by a hyperactive immune response; and (iv) the same components of the neuro-immune axis that play key roles in brain development and immune function are heavily targeted by Aluminum adjuvants.
In summary, research evidence shows that increasing concerns about current vaccination practices may indeed be warranted. Because children may be most at risk of vaccine-induced complications, a rigorous evaluation of the vaccine-related adverse health impacts in the pediatric population is urgently needed."

http://www.ncbi.nlm.nih.gov/pubmed/22235057

• Influence of pediatric vaccines on amygdala growth and opioid ligand binding in rhesus macaque infants: A pilot study

"In this pilot study, infant macaques receiving the recommended pediatric vaccine regimen from the 1990’s displayed a different pattern of maturational changes in amygdala volume and differences in amygdala-binding of [11C]DPN following the MMR/DTaP/Hib vaccinations between T1 and T2 compared with non-exposed animals. There was also evidence of greater total brain volume in the exposed group prior to these vaccinations suggesting a possible effect of previous vaccinations to which these animals had been exposed. Because primate testing is an important aspect of pre-clinical vaccine safety assessment prior to approval for human use (Kennedy et al. 1997), the results of this pilot study warrant additional research into the potential impact of an interaction between the MMR and thimerosal-containing vaccines on brain structure and function."

http://www.ane.pl/pdf/7020.pdf

Empirical Data Confirm Autism Symptoms Related to Aluminum and Acetaminophen Exposure- Entropy 2012, doi:10.3390/e14112227


"Autism is a condition characterized by impaired cognitive and social skills, associated with compromised immune function. The incidence is alarmingly on the rise, and environmental factors are increasingly suspected to play a role. This paper investigates word frequency patterns in the U.S. CDC Vaccine Adverse Events Reporting System (VAERS) database. Our results provide strong evidence supporting a link between autism and the aluminum in vaccines. A literature review showing toxicity of aluminum in human physiology offers further support. Mentions of autism in VAERS increased steadily at the end of the last century, during a period when mercury was being phased out, while aluminum adjuvant burden was being increased. Using standard log-likelihood ratio techniques, we identify several signs and symptoms that are significantly more prevalent in vaccine reports after 2000, including cellulitis, seizure, depression, fatigue, pain and death, which are also significantly associated with aluminum-containing vaccines. We propose that children with the autism diagnosis are especially vulnerable to toxic metals such as aluminum and mercury due to insufficient serum sulfate and glutathione. A strong correlation between autism and the MMR (Measles, Mumps, Rubella) vaccine is also observed, which may be partially explained via an increased sensitivity to acetaminophen administered to control fever."

 

Article belongs to the Special Issue Biosemiotic Entropy: Disorder, Disease, and Mortality
http://www.mdpi.com/1099-4300/14/11/2227


 


"These findings are consistent with the hypothesis that immunization with the recombinant hepatitis B vaccine is associated with an increased risk of MS, and challenge the idea that the relation between hepatitis B vaccination and risk of MS is well understood. "


http://www.neurology.org/content/63/5/838.abstract


"Hepatitis B vaccination does not "generally" increase the risk of CNS inflammatory demyelination in childhood. However, the Engerix B vaccine appears to increase this risk, particularly for confirmed multiple sclerosis, in the longer term."


http://www.ncbi.nlm.nih.gov/pubmed/18843097

Vaccinations create more powerful and virulent strains of bacteria and viruses.  The reason for the current whooping cough outbreak. Read more here from the CDC

"Vaccination against 2 avian viruses, the Marek disease virus, and the infectious bursal disease virus, were associated with the emergence of more virulent strains (33). An important role of host immunity in selecting for virulence is also suggested by the co-evolution of the myxomatosis virus and rabbits (34). Furthermore, immune pressure was shown to select for more virulent Plasmodium chabaudi parasites in mice (35). Based on mathematical modeling, vaccines designed to reduce pathogen growth rate and/or toxicity may result in the evolution of pathogens with higher levels of virulence (36)."

http://wwwnc.cdc.gov/eid/article/15/8/08-1511_article.htm

"A majority of the ophthalmological complications seen following hepatitis B vaccination consist of vision loss, optic neuritis, papillary edema, uveitis, acute placoid pigment epitheliopathy and central vein occlusion. We present a 9-year-old girl who was referred to our hospital with decrease in vision and pain in the left eye a week after hepatitis B vaccination. A diagnosis of vaccine induced optic neuritis was made."

http://www.ncbi.nlm.nih.gov/pubmed/19948437


 


WHAT DOES THIS SAY ABOUT THE VACCINATED POPULATIONS HEALTH?

​"Most high-risk medical conditions that were measured were more prevalent among vaccinated than among unvaccinated persons."

 

http://www.nejm.org/doi/pdf/10.1056/NEJMoa070844

"Furthermore, while India has been polio-free for a year, there has been a huge increase in non-polio acute flaccid paralysis (NPAFP). In 2011, there were an extra 47,500 new cases of NPAFP. Clinically indistinguishable from polio paralysis but twice as deadly, the incidence of NPAFP was directly proportional to doses of oral polio received. Though this data was collected within the polio surveillance system, it was not investigated."

http://www.ncbi.nlm.nih.gov/pubmed/22591873


Acute Fulminant Myocarditis after Diphtheria, Polio, and Tetanus Vaccination

"We report an infant case of acute fulminant myocarditis which occurred after administration of a diphtheria, polio, and tetanus vaccination. Fever and dyspnea developed after the vaccination. Extracorporeal membrane oxygenation was used for intractable cardiogenic shock. The patient survived the extracorporeal support, but poor ventricular contractility recurred 2 months later and she died while waiting for heart transplantation. " "Hypersensitivity myocarditis due to vaccination has been reported sporadically.1–4 Occurrence of early fever after vaccination, negative results of microbial culture and the absence of associated symptoms for diphtheria, polio, and tetanus favor the diagnosis of hypersensitivity myocarditis. However, there was no definite evidence to support a causal link between the administration of vaccines and myocarditis. Repeated antigen injection is a well-established provocation test to substantiate a causal relationship, however this in itself raises ethical dilemmas."

(so keep doing it without knowing?)

 

http://www.ncbi.nlm.nih.gov/pubmed/17130313
 

"No safety comparisons could be carried out, emphasising the need for standardisation of methods and presentation of vaccine safety data in future studies. In specific cases, influenza vaccines were associated with serious harms such as narcolepsy and febrile convulsions. It was surprising to find only one study of inactivated vaccine in children under two years, given current recommendations to vaccinate healthy children from six months of age in the USA, Canada, parts of Europe and Australia. If immunisation in children is to be recommended as a public health policy, large-scale studies assessing important outcomes, and directly comparing vaccine types are urgently required. The degree of scrutiny needed to identify all global cases of potential harms is beyond the resources of this review. This review includes trials funded by industry."

Studies funded from public sources were significantly less likely to report conclusions favorable to the vaccines. The review showed that reliable evidence on influenza vaccines is thin .... there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies." 2012

 

 

http://www.ncbi.nlm.nih.gov/pubmed/22895945

 

 

Serotype replacement:

"BACKGROUND:

In late spring 2009, concern was raised in Canada that prior vaccination with the 2008-09 trivalent inactivated influenza vaccine (TIV) was associated with increased risk of pandemic influenza A (H1N1) (pH1N1) illness. Several epidemiologic investigations were conducted through the summer to assess this putative association.

CONCLUSIONS: Prior receipt of 2008-09 TIV was associated with increased risk of medically attended pH1N1 illness during the spring-summer 2009 in Canada."

http://www.ncbi.nlm.nih.gov/pubmed/20386731

 

 

 

“Over the following 9 months, TIV (vaccine) recipients had an increased risk of virologically-confirmed non-influenza infections….

“There was no statistically significant difference in the risk of confirmed seasonal influenza infection between recipients of TIV (vaccine) or placebo, although the point estimate was consistent with protection in TIV recipient... TIV recipients had significantly lower risk of seasonal influenza infection based on serologic evidence…However, participants who received TIV (vaccine) had higher risk of Acute Respiratory Infections associated with confirmed noninfluenza respiratory virus infection. Including 2 additional confirmed infections when participants did not report ARI, TIV (vaccine) recipients had higher risk of confirmed noninfluenza respiratory virus infection. The majority of the noninfluenza respiratory virus detections were rhinoviruses and coxsackie/echoviruses, and the increased risk among TIV recipients was also statistically significant for these viruses….” 2012

http://www.ncbi.nlm.nih.gov/pubmed/22423139
 

 

Low 2012-13 influenza vaccine effectiveness associated with mutation in the egg-adapted H3N2 vaccine strain not antigenic drift in circulating viruses.

 

BACKGROUND:

Influenza vaccine effectiveness (VE) is generally interpreted in the context of vaccine match/mismatch to circulating strains with evolutionary drift in the latter invoked to explain reduced protection. During the 2012-13 season, however, detailed genotypic and phenotypic characterization shows that low vaccine effectiveness was instead related to mutations in the egg-adapted H3N2 vaccine strain rather than antigenic drift in circulating viruses.

The egg-adapted strain was itself antigenically distinct from the WHO-recommended prototype, and bore three AA mutations at antigenic sites B [H156Q, G186V] and D [S219Y]. Conversely, circulating viruses were identical to the WHO-recommended prototype at these positions with other genetic variation that did not affect antigenicity.

 

These findings underscore the need to monitor vaccine viruses as well as circulating strains to explain vaccine performance. Evolutionary drift in circulating viruses cannot be regulated, but influential mutations introduced as part of egg-based vaccine production may be amenable to improvements. {ya think?!}
2014


http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965421/


http://www.ncbi.nlm.nih.gov/pubmed/24667168

 

 


Impact of Repeated Vaccination on Vaccine Effectiveness Against Influenza A(H3N2) and B During 8 Seasons

"In the analysis using 5 years of historical vaccination data, current season VE against H3N2 was significantly higher among vaccinated individuals with no prior vaccination history compared with vaccinated individuals with a frequent vaccination history.......
vaccine-induced protection was greatest for individuals not vaccinated during the prior 5 years. Additional studies are needed to understand the long-term effects of annual vaccination" NOV 2014

{Since children and infants receive 26 doses by the first year of life I assume they wouldnt get protection}

"the analysis using 5 years of historical vaccination data suggested a significant difference in current-season vaccine effectiveness among frequent vaccinees compared with nonvaccinees. Interference due to repeated prior vaccination is one possible explanation for this difference, but unmeasured confounding could also account for the observed differences. The potential immunologic mechanisms for vaccine interference are not well understood. Contributing factors may include “original antigenic sin,” immune exhaustion, and/or antigenic drift of circulating influenza viruses with respect to vaccine antigens....
The evidence of original antigenic sin is strongest for sequential natural influenza infections. It is unclear whether repeated influenza vaccination generates effects of similar magnitude."

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207422/
 

 

 

Increased Risk of Noninfluenza Respiratory Virus Infections Associated With Receipt of Inactivated Influenza Vaccine

“Receipt of TIV could increase influenza immunity at the expense of reduced immunity to noninfluenza respiratory viruses, by some unknown biological mechanism.....Participants who received TIV would have been protected against influenza in February 2009 but then would not have had heightened nonspecific immunity in the following weeks. They would then face a higher risk of certain other virus infections in March 2009, compared with placebo recipients (Figure 1). The duration of any temporary nonspecific immunity remains uncertain but could be of the order of 2–4 weeks based on these observations.” 2012

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404712/  

 

Epidemiology of respiratory viral infections in children enrolled in a study of influenza vaccine effectiveness

 

“Influenza-vaccinated children were 1·6 times more likely than unvaccinated children to have a non-influenza influenza like illness……
Non-influenza Influenza Like Ilnesses were more common among fully vaccinated and partially vaccinated subjects than among unvaccinated subjects …Excluding Influenza Like Ilnesses from which no virus was identified made no significant difference to this finding.” 2014

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181477/

 

"Repeated immunization with antigen causes systemic autoimmunity in mice otherwise not prone to spontaneous autoimmune diseases. Overstimulation of CD4+ T cells led to the development of autoantibody-inducing CD4+ T (aiCD4+ T) cell which had undergone T cell receptor (TCR) revision and was capable of inducing autoantibodies."
"Systemic autoimmunity appears to be the inevitable consequence of over-stimulating the host's immune ‘system’ by repeated immunization with antigen, to the levels that surpass system's self-organized criticality."


http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795160/

"Vaccine-type rotavirus was detected in all 50 antigen-positive specimens and 8 of 8 antigen-negative specimens. Nine (75%) of 12 EIA-positive and 1 EIA-negative samples tested culture-positive for vaccine-type rotavirus. Fecal shedding of rotavirus vaccine virus after the first dose of RV5 occurred over a wide range of post-vaccination days not previously studied."

http://www.ncbi.nlm.nih.gov/pubmed/21477676


Effectiveness of trivalent inactivated influenza vaccine in influenza-related hospitalization in children: a case-control study.
 

"Using the Cochran-Mantel-Haenszel test for asthma status stratification, there was a significant association between hospitalization in asthmatic subjects and TIV (vaccine). TIV did not provide any protection against hospitalization in pediatric subjects, especially children with asthma. On the contrary, we found a threefold increased risk of hospitalization in subjects who did get the TIV vaccine. This may be a reflection not only of vaccine effectiveness but also the population of children who are more likely to get the vaccine." Allergy Asthma Proc. 2012 Mar-Apr;33(2):e23-7.

http://www.ncbi.nlm.nih.gov/pubmed/22525386

"The odds of having a history of asthma was twice as great among vaccinated subjects than among unvaccinated subjects  The odds of having had any allergy-related respiratory symptom in the past 12 months was 63% greater among vaccinated subjects than unvaccinated subjects"

http://www.ncbi.nlm.nih.gov/pubmed/10714532

"The 23 children who received no diphtheria/pertussis/tetanus (DPT) and polio immunizations had no recorded asthma episodes or consultations for asthma or other allergic illness before age 10 years; in the immunized children, 23.1% had asthma episodes, 22.5% asthma consultations, and 30.0% consultations for other allergic illness. Similar differences were observed at ages 5 and 16 years. These findings do not appear to be due to differential use of health services (although this possibility cannot be excluded) or con-founding by ethnicity, socioeconomic status, parental atopy, or parental smoking."
 

http://www.ncbi.nlm.nih.gov/pubmed/9345669/  

 

"Conclusions (THE ONLY THING THAT SHOULD MATTER) There are significantly elevated risks of primarily emergency room visits approximately one to two weeks following 12 and 18 month vaccination. Future studies should examine whether these events could be predicted or prevented." 

     
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236196/


Administration of thimerosal to infant rats increases overflow of glutamate and aspartate in the prefrontal cortex: protective role of dehydroepiandrosterone sulfate.          

http://www.ncbi.nlm.nih.gov/pubmed/22015977


Lasting neuropathological changes in rat brain after intermittent neonatal administration of thimerosal. “These findings document neurotoxic effects of thimerosal, at doses equivalent to those used in infant vaccines or higher, in developing rat brain, suggesting likely involvement of this mercurial in neurodevelopmental disorders”

http://www.ncbi.nlm.nih.gov/pubmed/21225508

•Download FEDERAL COURT CASE - BAILEYS PERVASIVE DEVELOPMENTAL DISORDER/Autism Spectrum Disorder
"the MMR vaccine at issue actually caused the condition(s) from which Bailey suffered and continues to suffer"


http://www.generationrescue.org/resources/vaccination/vaccine-related-court-cases/bailey-banks/
 

• “An acellular whooping cough vaccine actually enhances the colonization of Bordetella parapertussis in mice; pointing towards a rise in B. parapertussis incidence resulting from acellular vaccination, which may have contributed to the observed increase in whooping cough over the last decade”.

http://www.cidd.psu.edu/research/synopses/acellular-vaccine-enhancement-b.-parapertussis

• “Our data suggests that the current schedule of acellular pertussis vaccine doses is insufficient to prevent outbreaks of pertussis.”

http://cid.oxfordjournals.org/content/early/2012/03/13/cid.cis287.short

"The observation that aP (pertussis vaccination), which induces an immune response mismatched to that induced by natural infection,
fails to prevent colonization or transmission provides a plausible explanation for the resurgence of pertussis..."


http://www.ncbi.nlm.nih.gov/pubmed/24277828

 

 

"Thus, we conclude that aP (whooping cough) vaccination interferes with the optimal clearance of B. parapertussis and *enhances the *performance of this *pathogen. Our data raise the possibility that *widespread aP vaccination *can *create *hosts *more *susceptible to B. parapertussis infection."

 

http://www.ncbi.nlm.nih.gov/pubmed/20200027

 

 

VACCINES SPREAD DISEASE
 

“Baboons vaccinated with aP (pertussis vaccine) were protected from severe pertussis-associated symptoms (NOT TRUE) but not from colonization (infection), DID NOT clear the infection faster than naïve (unvaccinated) animals, and READILY transmitted B. pertussis to unvaccinated contacts.” 2013
 

http://www.ncbi.nlm.nih.gov/pubmed/24277828  or
 

http://www.accessdata.fda.gov/scripts/publications/search_result_record.cfm?id=48636

•    “Our unvaccinated and under-vaccinated population did not appear to contribute significantly to the increased rate of clinical pertussis. Surprisingly, the highest incidence of disease was among previously vaccinated children in the eight to twelve year age group.”

http://www.ncbi.nlm.nih.gov/pubmed/22423127


THERE ARE OTHER UNINTENDED VIRUSES, MYCOPLASMAS, PARASITES AND BACTERIA IN VACCINES AND WE HAVE SEEN THIS OVER AND OVER 

• Investigations of porcine circovirus type 1 (PCV1) in vaccine-related and other cell lines. “Porcine circovirus type 1 (PCV1) is highly prevalent in swine and was recently reported in some rotavirus vaccines.”  Epub 2011 Aug 9.

http://www.ncbi.nlm.nih.gov/pubmed/21835219?dopt=Abstract

ABORTED FETAL CELL LINES- "In some cases the cell lines (aborted fetal cell lines) that are used might be tumorigenic, that is, they form tumors when injected into rodents. Some of these tumor-forming cell lines may contain cancer-causing viruses that are not actively reproducing. Such viruses are hard to detect using standard methods. These latent, or "quiet," viruses pose a potential threat, since they might become active under vaccine manufacturing conditions.”

WOULD YOU RISK THIS ON YOUR CHILD????
http://www.fda.gov/biologicsbloodvaccines/scienceresearch/biologicsresearcha
reas/ucm127327.htm

'Xenotropic murine leukemia virus-related virus (XMRV) is a recently discovered human retrovirus that has been found in both chronic fatigue syndrome & prostate cancer patients. There is a potential safety concern regarding XMRV in cell substrates used in vaccines...'

 

http://www.fda.gov/biologicsbloodvaccines/scienceresearch/biologicsresearchareas/ucm127327.htm
 

"The use of tumorigenic and tumor-derived cells is a major safety concern due to the potential presence of viruses such as retroviruses and oncogenic (CANCER) DNA viruses that could be associated with tumorigencity, Therefore, detection of persistent, latent DNA viruses, and endogenous retroviruses in vaccine cell substrates is important for vaccine safety, particularly in the development of live viral vaccines, where there are no or minimal virus inactivation and removal steps during vaccine manufacturing."

 

http://www.fda.gov/biologicsbloodvaccines/scienceresearch/biologicsresearchareas/ucm127327.htm

 

NO aborted fetal DNA IS SAFE TO INJECT! 23 vaccines today contain them.

"It is known from gene therapy studies that injected naked DNA can be transported to the brain (Wang et al. 2001); that improperly integrated therapeutic DNA has caused cancer in young children (Hacein-Bey-Abina et al. 2008); and that shorter DNA fragments have a higher probability of entering the nucleus [of the cells] (Lechardeur et al. 2002)", noted Dr Theresa whose company recently received a $500,000 grant from the Murdock foundation for their research.

"Changepoint analysis of autism disorder demonstrates a temporal correlation with events associated with human DNA residuals in vaccines. The levels of residual DNA are well over FDA-recommended limits", stated Dr Deisher.

"Meruvax-II contains >140ng/vial ssDNA and >30ng/vial dsDNA, with average lengths of 215bp. Havrix contains >270ng/vial ssDNA and >30ng/vial dsDNA. The FDA-recommended amounts are 10ng/dose."

http://www.cogforlife.org/scpiautismstudypress.htm

"Unvaccinated children tended to be white, to have a mother who was married and had a college degree, to live in a household with an annual income exceeding $75,000 dollars, and to have parents who expressed concerns regarding the safety of vaccines and indicated that medical doctors have little influence over vaccination decisions for their children."

http://www.ncbi.nlm.nih.gov/pubmed/15231927


"Although persons often use vaccination and immunization interchangeably in reference to active immunization (VACCINES), the terms are not synonomous because the administration of an immunobiologic cannot be automatically equated with the development of adequate immunity."

http://www.cdc.gov/mmwr/PDF/rr/rr4301.pdf


"Hib immunization contributed to an increased risk for H. influenzae type a meningitis through selection of  circulating H. influenzae type a clones." " the incidence for H. influenzae type a meningitis increased 8-fold"

http://jid.oxfordjournals.org/content/187/1/109.full.pdf+html

"Virus-induced autoimmunity may play a causal role in autism. To examine the etiologic link of viruses in this brain disorder, we conducted a serologic study of measles virus, mumps virus, and rubella virus. Viral antibodies were measured by enzyme-linked immunosorbent assay in the serum of autistic children, normal children, and siblings of autistic children. The level of measles antibody, but not mumps or rubella antibodies, was significantly higher in autistic children as compared with normal children (P = 0.003) or siblings of autistic children (P <or= 0.0001). Furthermore, immunoblotting of measles vaccine virus revealed that the antibody was directed against a protein of approximately 74 kd molecular weight. The antibody to this antigen was found in 83% of autistic children but not in normal children or siblings of autistic children. Thus autistic children have a hyperimmune response to measles virus, which in the absence of a wild type of measles infection might be a sign of an abnormal immune reaction to the vaccine strain or virus reactivation."

http://www.ncbi.nlm.nih.gov/pubmed/12849883

"Thus vaccination DOES NOT account for the impressive declines in mortality seen in the first half of the century" - 2000

http://pediatrics.aappublications.org/content/106/6/1307.abstract

Annual Summary of Vital Statistics: Trends in the Health of Americans During the 20th Century Guyer, et al. American Academy of Pediatrics 2000;
 

"However, in 2001, the vaccine was found to cause a serious, frequently fatal, multisystemic illness, called yellow fever vaccine–associated viscerotropic disease (YEL-AVD), which resembles the illness it was designed to prevent."

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310656/

"Our findings show a positive correlation between the number of vaccine doses administered and the percentage of hospitalizations and deaths. Since vaccines are given to millions of infants annually, it is imperative that health authorities have scientific data from synergistic toxicity studies on all combinations of vaccines that infants might receive. "

 

http://het.sagepub.com/content/31/10/1012.abstract?

Maternal transfer of mercury to the developing embryo/fetus: is there a safe level? "This study focused on standardized embryonic and fetal Hg exposures via primary exposure to the pregnant mother of two common Hg sources (dietary fish and parenteral vaccines). Data demonstrated that Hg exposures, particularly during the first trimester of pregnancy, at well-established dose/weight ratios produced severe damage to humans including death. " 


Toxicological & Environmental Chemistry Vol 94 2012

http://www.tandfonline.com/doi/full/10.1080/02772248.2012.724574


"reporting bias was too low to explain the magnitude increase in fetal-demise reporting rates in the VAERS database relative to the reported annual trends. Thus, a synergistic fetal toxicity likely resulted from the administration of both the pandemic (A-H1N1) and seasonal influenza vaccines during the 2009/2010 season."


http://www.ncbi.nlm.nih.gov/pubmed/23023030


"Hepatitis B vaccine might be followed by various rheumatic conditions and might trigger the onset of underlying inflammatory or autoimmune rheumatic diseases. "

 

http://www.ncbi.nlm.nih.gov/pubmed/10534549
 

"Autoimmunity to the central nervous system (CNS), especially to myelin basic protein (MBP), may play a causal role in autism, a neurodevelopmental disorder. Because many autistic children harbor elevated levels of measles antibodies, we conducted a serological study of measles-mumps-rubella (MMR) and MBP autoantibodies. Using serum samples of 125 autistic children and 92 control children, antibodies were assayed by ELISA or immunoblotting methods. ELISA analysis showed a significant increase in the level of MMR antibodies in autistic children. Immunoblotting analysis revealed the presence of an unusual MMR antibody in 75 of 125 (60%) autistic sera but not in control sera. This antibody specifically detected a protein of 73-75 kD of MMR. This protein band, as analyzed with monoclonal anti bodies, was immunopositive for measles hemagglutinin (HA) protein but not for measles nucleoprotein and rubella or mumps viral proteins. Thus the MMR antibody in autistic sera detected measles HA protein, which is unique to the measles subunit of the vaccine. Furthermore, over 90% of MMR antibody-positive autistic sera were also positive for MBP autoantibodies, suggesting a strong association between MMR and CNS autoimmunity in autism. Stemming from this evidence, we suggest that an inappropriate antibody response to MMR, specifically the measles component thereof, might be related to pathogenesis of autism."

 

http://www.ncbi.nlm.nih.gov/pubmed/12145534


Myocarditis, Pericarditis, and Dilated Cardiomyopathy after Smallpox Vaccination among Civilians in the United States, January–October 2003

"We describe an association between smallpox vaccination, using the US vaccinia strain, and myo/pericarditis among civilians."
"Most civilian vaccine recipients (75%) and case patients with myo/pericarditis (86%) were revaccinees. In contrast, Arness et al. found a 7.46 unadjusted risk among primary vaccinees in the US military and suggest that their findings support a causal relationship between smallpox vaccination and myo/pericarditis only among primary vaccinees."
"Given the now-documented association between smallpox vaccine and myo/pericarditis, it is biologically plausible that the 3 case patients who we identified may have been the result of the progression of vaccinia-induced myocarditis to DCM."

 

http://cid.oxfordjournals.org/content/46/Supplement_3/S242.abstract

 

 

Myocarditis after triple immunisation.

"We describe a 3 month old infant who developed myocarditis several hours after diphtheria, tetanus, and pertussis vaccination. The time of occurrence of symptoms, the clinical course, and the negative virological studies suggest a possible cardiogenic adverse reaction to the vaccine.
"Helle et al found electrocardiogram changes suggestive of myocarditis without evidence of cardiac disease in 3% of a study population consisting of new army recruits after vaccination against diphtheria and smallpox. In addition, several episodes of paroxysmal supraventricular tachycardia were observed within a few hours after diphtheria, tetanus, and pertussis immunisation in a 2 month old infant prone to paroxysmal supraventricular tachycardia."
"We believe that the myocardial reaction described was associated with the diphtheria, tetanus, and pertussis vaccination. Of the three components of the vaccine, either the diphtheria or the pertussis component probably provoked the myocardial damage."

http://adc.bmj.com/content/61/4/403.abstract?ijkey=ee2ab5c4267d41d3c818eed8af9bea8e892c8d65&keytype2=tf_ipsecsha


Myocarditis after Smallpox Vaccination: A Case Report

"A 20-year-old airman (US Air Force) developed myocarditis 8 days after smallpox vaccination. He was treated with nonsteroidal  anti-inflammatory agents, and his symptoms promptly resolved. However, postvaccinial myocarditis can lead to serious complications and even death."
"This patient clearly had myocarditis in temporal relation to primary smallpox vaccination. Viral and postviral myocarditis has been described in young servicemen, and therefore we tried aggressively to rule out nonvaccinial causes of the cardiac abnormalities in this patient, including common viral, autoimmune, bacterial, and toxicological etiologies. Several similar cases of postvaccinial myocarditis have recently been detected in US servicemen (J. Grabenstein, written communications, February and March 2003). Currently, the longterm prognosis of this condition is not known."


"Clinicians providing care to patients who have chest complaints after smallpox vaccination should be aware of the existence of postvaccinial myocarditis, which seems to be more common than previously thought."

http://cid.oxfordjournals.org/content/37/1/145.full.pdf+html

 

"We report the first cases of tissue-proven eosinophilic myocarditis after single vaccine administration of conjugate meningococcal C and hepatitis B vaccine, respectively. The nature of histopathologic findings strongly supports hypersensitivity reaction....To enhance discussion of our cases, we performed a systematic review of the literature on postimmunization myocarditis or pericarditis, and identified 37 publications, reporting 269 cases during the search period (1966-2007). Time of onset of cardiac symptoms in all patients ranged from 1 to 30 days postimmunization." 2008

 

http://www.ncbi.nlm.nih.gov/pubmed/18664932

 


A case series of children with apparent mercury toxic encephalopathies manifesting with clinical symptoms of regressive autistic disorders.

Impairments in social relatedness and communication, repetitive behaviors, and stereotypic abnormal movement patterns characterize autism spectrum disorders (ASDs). It is clear that while genetic factors are important to the pathogenesis of ASDs, mercury exposure can induce immune, sensory, neurological, motor, and behavioral dysfunctions similar to traits defining or associated with ASDs. The Institutional Review Board of the Institute for Chronic Illnesses (Office for Human Research Protections, U.S. Department of Health and Human Services, IRB number IRB00005375) approved the present study. A case series of nine patients who presented to the Genetic Centers of America for a genetic/developmental evaluation are discussed. Eight of nine patients (one patient was found to have an ASD due to Rett's syndrome) (a) had regressive ASDs; (b) had elevated levels of androgens; (c) excreted significant amounts of mercury post chelation challenge; (d) had biochemical evidence of decreased function in their glutathione pathways; (e) had no known significant mercury exposure except from Thimerosal-containing vaccines/Rho(D)-immune globulin preparations; and (f) had alternate causes for their regressive ASDs ruled out. There was a significant dose-response relationship between the severity of the regressive ASDs observed and the total mercury dose children received from Thimerosal-containing vaccines/Rho (D)-immune globulin preparations. Based upon differential diagnoses, 8 of 9 patients examined were exposed to significant mercury from Thimerosal-containing biologic/vaccine preparations during their fetal/infant developmental periods, and subsequently, between 12 and 24 mo of age, these previously normally developing children suffered mercury toxic encephalopathies that manifested with clinical symptoms consistent with regressive ASDs. Evidence for mercury intoxication should be considered in the differential diagnosis as contributing to some regressive ASDs.

http://www.ncbi.nlm.nih.gov/pubmed/17454560


Autism: a novel form of mercury poisoning

"Thimerosal, a preservative added to many vaccines, has become a major source of mercury in children who, within their first two years, may have received a quantity of mercury that exceeds safety guidelines. A review of medical literature and US government data suggests that: (i) many cases of idiopathic autism are induced by early mercury exposure from thimerosal; (ii) this type of autism represents an unrecognized mercurial syndrome; and (iii) genetic and non-genetic factors establish a predisposition whereby thimerosal's adverse effects occur only in some children."

http://www.ncbi.nlm.nih.gov/pubmed/11339848

Annual influenza vaccination affects the development of heterosubtypic immunity. 2012 May 27.

Annual vaccination of healthy children >6 months of age against seasonal influenza has been recommended by public health authorities of some countries. However, currently used seasonal vaccines provide only limited protection against (potentially) pandemic influenza viruses. Furthermore, we recently hypothesized that annual vaccination may hamper the development of cross-reactive immunity against influenza A viruses of novel subtypes, that would otherwise be induced by natural infection. Here we summarize our findings in animal models in which we demonstrated that vaccination against influenza A/H3N2 virus reduced the induction of heterosubtypic immunity against highly pathogenic avian influenza A/H5N1 virus, otherwise induced by a prior infection with influenza A/H3N2 virus. The reduction of heterosubtypic immunity correlated with reduced virus-specific CD8+ T cell responses. An additional study was performed in humans, in which we collected peripheral blood mononuclear cells from annually vaccinated children with cystic fibrosis (CF) and age-matched unvaccinated healthy control children to study the virus-specific T cell response. An age-related increase of the virus-specific CD8+ T cell response was observed in unvaccinated children that was absent in vaccinated children with CF. These findings highlight the importance of the development of vaccines that provide protection against influenza A viruses of all subtypes. PMID: 22643217

 

http://www.ncbi.nlm.nih.gov/pubmed/22643217

"Together with an inflammatory reaction, influenza A vaccine induced platelet activation and sympathovagal imbalance towards adrenergic predominance. Significant correlations were found between CRP levels and HRV parameters, suggesting a pathophysiological link between inflammation and cardiac autonomic regulation. The vaccine-related platelet activation and cardiac autonomic dysfunction may transiently increase the risk of cardiovascular events."

http://www.ncbi.nlm.nih.gov/pubmed/20964738


"During 2009-2010 they found that the risk of narcolepsy among people aged 4-19 years old who had received pandemic influenza vaccine was nine times higher than that among those who had not been vaccinated."

http://www.who.int/vaccine_safety/committee/topics/influenza/pandemic/h1n1_safety_assessing/narcolepsy_statement/en/index.html


"In August 2010 concerns were raised in Finland and Sweden about a possible association between narcolepsy and Pandemrix.13 A subsequent cohort study in Finland reported a 13-fold increased risk of narcolepsy after vaccination in children and young people aged 4-19, most of whom had onset within three months after vaccination and almost all within six months"

"The increased risk of narcolepsy after vaccination with ASO3 adjuvanted pandemic A/H1N1 2009 vaccine indicates a causal association, consistent with findings from Finland."

http://www.bmj.com/content/346/bmj.f794


Acetaminophen use after measles-mumps-rubella vaccination was SIGNIFICANTLY associated with autistic disorder when considering children 5 years of age or less, after limiting cases to children with regression in development and when considering only children who had post-vaccination sequelae adjusting for age, gender, mother's ethnicity, and the presence of illness concurrent with measles-mumps-rubella vaccination. Ibuprofen use after measles-mumps-rubella vaccination was not associated with autistic disorder. This preliminary study found that acetaminophen use after measles-mumps-rubella vaccination was associated with autistic disorder.

http://www.ncbi.nlm.nih.gov/pubmed/18445737


"A positive and statistically significant relationship was found: The higher the proportion of children receiving recommended vaccinations, the higher was the prevalence of AUT (autism) or SLI (speech or language impairment ). A 1% increase in vaccination was associated with an additional 680 children having AUT or SLI. Neither parental behavior nor access to care affected the results, since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a U.S. state. The results suggest that although mercury has been removed from many vaccines, other culprits may link vaccines to autism. Further study into the relationship between vaccines and autism is warranted"

http://www.ncbi.nlm.nih.gov/pubmed/21623535


Detection of Measles Virus Genomic RNA in Cerebrospinal Fluid of
Children with Regressive Autism: a Report of Three Cases. J Am Phys
Surg, Vol 9 No 2, 2004.

In light of encephalopathy presenting as autistic regression (autistic encephalopathy, AE) closely following measles-mumps- rubella (MMR) vaccination, three children underwent cerebrospinal fluid(CSF) assessments including studies for measles virus(MV). All three children had concomitant onset of gastrointestinal (GI) symptoms and had already had MV genomic RNA detected in biopsies ofileal lymphoid nodular hyperplasia(LNH). Presence of MV Fusion(F) gene was examined by TaqMan real- time quantitative polymerase chain reaction (RT-PCR) in cases and control CSF samples. The latter were obtained from three non- autistic MMR-vaccinated children with indwelling shunts for hydrocephalus. None of the cases or controls had a history of measles exposure other than MMR vaccination. Serum and CSF samples were also evaluated for antibodies to MV and myelin basic protein(MBP). MV F gene was present in CSF from all three cases, but not in controls. Genome copy number ranged from 3.7x10 to 2.42x10 per ng of RNA total. Serum anti-MBP autoantibodies were detected in all children with AE. Anti-MBP and MV antibodies were detected in the CSF of two cases, while the third child had neither anti-MBP nor MV antibodies detected in his CSF. Findings are consistent with both an MV (measles virus) etiology for the AE (autistic encephalopathy) and active viral replication in these children. They further indicate the possibility of a virally driven cerebral immunopathology in some cases of regressive autism.


Full PDF Download:

 

www.jpands.org/vol9no2/bradstreet.pdf

Delay in diphtheria, pertussis, tetanus vaccination is associated with a reduced risk of childhood asthma.

Early childhood immunizations have been viewed as promoters of asthma development by stimulating a T(H)2-type immune response or decreasing microbial pressure, which shifts the balance between T(H)1 and T(H)2 immunity.


OBJECTIVE:
Differing time schedules for childhood immunizations may explain the discrepant findings of an association with asthma reported in observational studies. This research was undertaken to determine whether timing of diphtheria, pertussis, tetanus (DPT) immunization has an effect on the development of childhood asthma by age 7 years.
RESULTS:
Among 11, 531 children who received at least 4 doses of DPT, the risk of asthma was reduced to (1/2) in children whose first dose of DPT was delayed by more than 2 months. The likelihood of asthma in children with delays in all 3 doses was 0.39 (95% CI, 0.18-0.86).
CONCLUSION:
We found a negative association between delay in administration of the first dose of whole-cell DPT immunization in childhood and the development of asthma; the association was greater with delays in all of the first 3 doses. The mechanism for this phenomenon requires further research.

http://www.ncbi.nlm.nih.gov/pubmed/18207561

 

"There is extensive bi-directional communication between the brain and the immune system in both health and disease. In recent years, the role of an altered immune system in the etiology of major psychiatric disorders has become more apparent. Studies have demonstrated that some patients with major psychiatric disorders exhibit characteristic signs of immune dysregulation and that this may be a common pathophysiological mechanism that underlies the development and progression of these disorders. Furthermore, many psychiatric disorders are also often accompanied by chronic medical conditions related to immune dysfunction such as autoimmune diseases, diabetes and atherosclerosis. One of the major psychiatric disorders that has been associated with an altered immune system is schizophrenia, with approximately one third of patients with this disorder showing immunological abnormalities such as an altered cytokine profile in serum and cerebrospinal fluid. An altered cytokine profile is also found in a proportion of patients with major depressive disorder and is thought to be potentially related to the pathophysiology of this disorder. Emerging evidence suggests that altered immune parameters may also be implicated in the neurobiological etiology of autism spectrum disorders. Further support for a role of immune dysregulation in the pathophysiology of these psychiatric disorders comes from studies showing the immunomodulating effects of antipsychotics and antidepressants, and the mood altering effects of anti-inflammatory therapies. This review will not attempt to discuss all of the psychiatric disorders that have been associated with an augmented immune system, but will instead focus on several key disorders where dysregulation of this system has been implicated in their pathophysiology including depression, schizophrenia and autism spectrum disorder."

http://www.ncbi.nlm.nih.gov/pubmed/23645137

"Macrophagic myofasciitis and chronic fatigue syndrome are severely disabling conditions which may be caused by adverse reactions to aluminium-containing adjuvants in vaccines. While a little is known of disease aetiology both conditions are characterised by an aberrant immune response, have a number of prominent symptoms in common and are coincident in many individuals. Herein, we have described a case of vaccine-associated chronic fatigue syndrome and macrophagic myofasciitis in an individual demonstrating aluminium overload. This is the first report linking the latter with either of these two conditions and the possibility is considered that the coincident aluminium overload contributed significantly to the severity of these conditions in this individual. This case has highlighted potential dangers associated with aluminium-containing adjuvants and we have elucidated a possible mechanism whereby vaccination involving aluminium-containing adjuvants could trigger the cascade of immunological events which are associated with autoimmune conditions including chronic fatigue syndrome and macrophagic myofasciitis.

http://www.ncbi.nlm.nih.gov/pubmed/19004564
 

Mayo Clinic Proc, Nov 2003

"Case.—A previously healthy 14-year-old boy presented with fever and intermittent (lasting a few minutes) chest pain. The symptoms developed 3 days after he had received a vaccination for tetanus (Tetavax, Aventis Pasteur SA, Lyon, France). His medical history was unremarkable except for a severe skin eruption that occurred after trimethoprim- sulfamethoxazole treatment when he was 8 yearsof age. He had no history of adverse reactions to tetanus or other vaccinations. One recent report described a case of myopericarditis after triple vaccination against diphtheria, tetanus, and poliovirus. The patient had symptoms similar to our patient’s, with slightly elevated cardiac enzymes and normal findings on echocardiography and coronary angiography. The vaccination was the suspected cause in view of the chronology of the symptoms. Performing a provocative test that would confirm the causal relationship between the vaccination and the cardiac anomalies would be unethical."


"Hypersensitivity myocarditis should be considered when new ECG changes occur in association with acute-onset chest pain, mildly elevated cardiac enzyme levels, and eosinophilia due to drugs and vaccination." 

Mayo Clin Proc, November 2003, Vol 78


Acute Myopericarditis After Multiple Vaccinations in an Adolescent: Case Report and Review of the Literature
 

"Our case highlights the fact that pediatricians should be aware of the often-dramatic presentation of postvaccination myopericarditis and its usually benign clinical course. The diagnosis of myocarditis should be entertained when acute-onset chest pain is accompanied by ECG changes and elevated cardiac enzyme levels. In cases in which the above-described presentation is temporally related to routine immunizations, the immunizations should be considered as a possible underlying etiology. "

"The vaccination that has received great attention recently is that for smallpox, particularly after reinstitution of the vaccination for military personnel in 2002 and the reports of >50 cases of probable myocarditis temporally related to it"
 

http://pediatrics.aappublications.org/content/119/6/e1400.full
 

TWINS SHARE 100% OF THEIR DNA, THEY SHOULD HAVE A 100% AUTISM RATE IF IT WERE COMPLETELY GENETIC, BUT THEY DONT! AUTISM IS CAUSED BY ENVIRONMENTAL FACTORS.

Results For strict autism, probandwise concordance for male twins was 0.58 for 40 monozygotic pairs (95% confidence interval [CI], 0.42-0.74) and 0.21 for 31 dizygotic pairs (95% CI, 0.09-0.43); for female twins, the concordance was 0.60 for 7 monozygotic pairs (95% CI, 0.28-0.90) and 0.27 for 10 dizygotic pairs (95% CI, 0.09-0.69). For ASD, the probandwise concordance for male twins was 0.77 for 45 monozygotic pairs (95% CI, 0.65-0.86) and 0.31 for 45 dizygotic pairs (95% CI, 0.16-0.46); for female twins, the concordance was 0.50 for 9 monozygotic pairs (95% CI, 0.16-0.84) and 0.36 for 13 dizygotic pairs (95% CI, 0.11-0.60). A large proportion of the variance in liability can be explained by shared environmental factors (55%; 95% CI, 9%-81% for autism and 58%; 95% CI, 30%-80% for ASD) in addition to moderate genetic heritability (37%; 95% CI, 8%-84% for autism and 38%; 95% CI, 14%-67% for ASD).
Conclusion Susceptibility to ASD has moderate genetic heritability and a substantial shared twin environmental component.

http://www.ncbi.nlm.nih.gov/pubmed/21727249

 


Mercury and autism: accelerating evidence?

Autism spectrum disorders (ASDs) also known as pervasive developmental disorders (PDD) are a behaviorally defined group of neurodevelopmental disorders that are usually diagnosed in early childhood. ASDs disproportionately affect male children. Mercury (Hg) a heavy metal, is widespread and persistent in the environment. Mercury is a ubiquitous source of danger in fish, drugs, fungicides/herbicides, dental fillings, thermometers, and many other products. Elevated Hg concentrations may remain in the brain from several years to decades following exposure. This is important because investigators have long recognized that Hg is a neurodevelopmental poison; it can cause problems in neuronal cell migration and division, and can ultimately cause cell degeneration and death. Case-reports of patients have described developmental regressions with ASD symptoms following fetal and/or early childhood Hg exposure, and epidemiological studies have linked exposure to Hg with an elevated risk of a patient being diagnosed with an ASD. Immune, sensory, neurological, motor, and behavioral dysfunctions similar to traits defining or associated with ASDs were reported following Hg (mercury) intoxication with similarities extending to neuroanatomy, neurotransmitters, and biochemistry. The sexual dimorphism of ASDs may result from synergistic neurotoxicity caused by the interaction of testosterone and Hg; in contrast, estrogen is protective, mitigating the toxicity of Hg. Mercury exposure may significantly increase androgen levels, and as a result, patients diagnosed with an ASD may significantly benefit from anti-androgen therapy. Finally, the clinical geneticist has a wealth of biomarkers to evaluate and treat patients diagnosed with an ASD.

http://www.ncbi.nlm.nih.gov/pubmed/16264412

"Varicella vaccination is less effective than the natural immunity that existed in prevaccine communities. Universal varicella vaccination has not proven to be cost-effective as increased HZ morbidity has disproportionately offset cost savings associated with reductions in varicella disease. Universal varicella vaccination has failed to provide long-term protection from VZV disease."             PMID: 20642419

 

http://www.ncbi.nlm.nih.gov/pubmed/22659447

"Clustering of cases of insulin dependent diabetes (IDDM) occurring three years after hemophilus influenza B (HiB) immunization support causal relationship between immunization and IDDM (insulin depedent diabetes)."
 
http://www.ncbi.nlm.nih.gov/pubmed/12911277

"We initiated and funded a collaborative study with Tuomilehto on the effect of the Haemophilus influenzae type b vaccine on type 1 diabetes and found that the data support a causal relation (paper submitted for publication). Furthermore, the potential risk of the vaccine exceeds the potential benefit."

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1116914/

" The studies aiming to prove the widespread belief that healthcare worker vaccination decreases patient morbidity and mortality are heavily flawed and the recommendations for vaccination biased. No reliable published evidence shows that healthcare workers' vaccination has substantial benefit for their patients—not in reducing patient morbidity or mortality and not even in increasing patient vaccination rates. Conclusion. The arguments for uniform healthcare worker influenza vaccination are not supported by existing literature. The decision whether to get vaccinated should, except possibly in extreme situations, be that of the individual healthcare worker, without legal, institutional, or peer coercion."

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502850/

"A fatal case of a 3-month-old female infant, who died within 24 h of vaccination with hexavalent vaccine is presented. Clinical data, post-mortem findings (acute pulmonary oedema, acute pulmonary emphysema), quali-quantitative data collected from immunohistochemical staining (degranulating mast cells) and laboratory analysis with a high level of beta-tryptase in serum, 43.3 microg/l, allows us to conclude that acute respiratory failure likely due to post hexavalent immunization-related shock was the cause of death."

http://www.ncbi.nlm.nih.gov/pubmed/18538957

"Despite wide use of the influenza vaccine, relatively little is known about its effect on the measurement of inflammatory markers. Because inflammatory markers such as C-reactive protein (CRP) are increasingly being used in conjunction with lipids for the clinical assessment of cardiovascular disease and in epidemiologic studies, we evaluated the effect of influenza vaccination on markers of inflammation and plasma lipid concentrations"
"Our findings show that the influenza vaccination causes transient changes in select markers of inflammation and lipids. Consequently, clinical and epidemiologic interpretation of the biomarkers affected should take into account the possible effects of influenza vaccination."

http://www.ncbi.nlm.nih.gov/pubmed/15976761


Polysorbate 80- an ingredient in vaccines- linked to infertility

"Neonatal female rats were injected ip (0.1 ml/rat) with Tween 80 in 1, 5 or 10% aqueous solution on days 4-7 after birth. Treatment with Tween 80 accelerated maturation, prolonged the oestrus cycle, and induced persistent vaginal oestrus. The relative weight of the uterus and ovaries was decreased relative to the untreated controls. Squamous cell metaplasia of the epithelial lining of the uterus and cytological changes in the uterus were indicative of chronic oestrogenic stimulation. Ovaries were without corpora lutea, and had degenerative follicles"

http://www.ncbi.nlm.nih.gov/pubmed/8473002?dopt=Abstract

"Acquired autoimmunity syndromes occur after viral vaccinations. Molecular mimicry is involved in these phenomena as is the necessity for the presence of two chemically complimentary antigens and an immunologic adjuvant. The HLA pattern of the host is also an important factor. The example used to explain these phenomena is demyelinating disease that follows hepatitis B vaccination. The somatic antigen of the hepatitis B virus in the vaccine has chemical complimentarity with the Epstein-Barr virus antigen in the vaccine recipient. The Epstein-Barr virus shows molecular mimicry with human myelin. The immunologic adjuvant is either present in the vaccine or muramyl peptides in the individual who is vaccinated. Why more than one type of autoimmune disease occurs is explained by the fact that specific autoimmune T-cells have been shown to develop clones that attack multiple human tissues." PMID: 17630224

http://www.ncbi.nlm.nih.gov/pubmed/17630224

"Universal hepatitis B vaccination was recommended for U.S. newborns in 1991; however, safety findings are mixed. The association between hepatitis B vaccination of male neonates and parental report of autism diagnosis was determined.  Logistic regression was used to estimate the odds for autism diagnosis associated with neonatal hepatitis B vaccination among boys age 3-17 years, born before 1999, adjusted for race, maternal education, and two-parent household. Boys vaccinated as neonates had threefold greater odds for autism diagnosis compared to boys never vaccinated or vaccinated after the first month of life. Non-Hispanic white boys were 64% less likely to have autism diagnosis relative to nonwhite boys. Findings suggest that U.S. male neonates vaccinated with the hepatitis B vaccine prior to 1999 (from vaccination record) had a threefold higher risk for parental report of autism diagnosis compared to boys not vaccinated as neonates during that same time period. Nonwhite boys bore a greater risk."

http://www.ncbi.nlm.nih.gov/pubmed/21058170

Shedding and immunocompromised children.
No matter what they say, those vaccine viruses shed. And youre sitting their saying please get vaccinated and shed to my immunocompromised child!  Shedding viruses cause disease too!

"Vaccine-type rotavirus was detected in all 50 antigen-positive specimens and 8 of 8 antigen-negative specimens. Nine (75%) of 12 EIA-positive and 1 EIA-negative samples tested culture-positive for vaccine-type rotavirus. Fecal shedding of rotavirus vaccine virus after the first dose of RV5 occurred over a wide range of post-vaccination days not previously studied."
 

http://www.ncbi.nlm.nih.gov/pubmed/21477676

“The FluMist influenza vaccine strains replicate in the nasopharynx and can be recovered and cultured from respiratory secretions of vaccinated individuals (shed).  The pattern and duration of shedding is important to understand because with prolonged shedding at high titer there is a theoretical risk of loss of attenuated phenotype, reassortment with wild-type influenza virus during influenza season, and transmission of vaccine virus to unvaccinated people, some of whom may be immuno-compromised and/or at risk for complications of live viral infections. “  “additional shedding samples collected every 7 days ... though some individuals shed vaccine strain virus as late as day 28”

www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/Approved

Products/UCM259175.pdf

“The RotaTeq vaccine contains five live, attenuated strains derived through laboratory reassortment of human rotavirus strains with a bovine rotavirus strain. Three RotaTeq strains each contain a single human rotavirus gene segment and ten bovine rotavirus segments, and two strains contain two human strain segments and nine bovine strain segments. In the study, RotaTeq was detected in 16 stool samples. Ten of these contained between one and four individual vaccine component strains. Six samples were found to contain a vaccine-derived G1P[8] (vdG1P[8]) strain. vdG1P[8] is believed to be the product of a genetic reassortment event in which the G1 gene segment of strain WI79-9 is inserted into strain WI79-4, as evidenced by the association of G1-VP7 and P[8]-VP4 human rotavirus genes with the M2-VP3 and I2-VP6 of the bovine rotavirus. Donato et al. observed that approximately a fifth of the infants having diarrhea within 2 weeks of rotavirus vaccination were shedding vaccine strain components exclusive of any detectable enteric pathogen.”

http://www.ncbi.nlm.nih.gov/pubmed/23249230


FULL TEXT http://www.expert-reviews.com/doi/full/10.1586/erv.12.114

"Analysis of 36 individuals over age 60 years who were immunized with  Zostavax revealed varicella zoster virus DNA in swabs of skin inoculation sites obtained immediately after immunization in 18 (50%) of 36 subjects  and in saliva collected over 28 days in 21 (58%) of 36 subjects. Genotypic analysis of DNA extracted from 9 random saliva samples identified vaccine virus in ALL instances. In some immunized individuals over age 60, vaccine virus DNA is shed in saliva up to 4 weeks."

"Zostavax contains live attenuated VZV, and the package insert warns newly vaccinated individuals to avoid contact for an unspecified time with newborn infants, immunosuppressed individuals, and pregnant women who have not had chicken pox or have not been immunized for chicken pox. Because VZV DNA is present in saliva of zoster patients for at least 2 weeks [5] and VZV in saliva can also be infectious [6], we examined the inoculation site and saliva of Zostavax-vaccinated subjects for the presence of VZV DNA for 4 weeks after immunization"


FULL TEXT   http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096786/

 

Stroke after varicella vaccination.

 

Two children presented with acute hemiparesis 5 days and 3 weeks following varicella vaccination. Both showed unilateral infarction of the basal ganglia and internal capsule, a distribution consistent with varicella angiopathy. Both children had small patent foramen ovale (PFO), and one child also had severe iron-deficiency anemia, which may have predisposed the patient to this adverse effect.

http://www.ncbi.nlm.nih.gov/pubmed/15580216/

Elevated blood histamine caused by vaccinations and Vitamin C deficiency may mimic the shaken baby syndrome.

"The findings of subdural hematoma and retinal hemorrhages in infants, without any documented history of major trauma, do not alw...ays indicate child abuse. A combination of ascorbate depletion and the injection of foreign proteins can cause a very high blood histamine level, leading to capillary fragility and venular bleeding. This can be prevented by the administration of vitamin C."

http://www.ncbi.nlm.nih.gov/pubmed/15050101

 

Human Papilloma Virus Vaccine and Primary Ovarian Failure: Another Facet of the Autoimmune/Inflammatory Syndrome Induced by Adjuvants.


"We documented here the evidence of the potential of the HPV vaccine to trigger a life-disabling autoimmune condition. The increasing number of similar reports of post HPV vaccine-linked autoimmunity and the uncertainty of long-term clinical benefits of HPV vaccination are a matter of public health that warrants further rigorous inquiry." JULY 31 2013

http://www.ncbi.nlm.nih.gov/pubmed/23902317

 

"For intramuscular and subcutaneous vaccinations, injections of sterile normal saline may serve as placebos, but researchers frequently choose other comparative agents. A review of the most recently published trials involving vaccines for children found a variety of comparators that took the place of placebos in children. For example, a recent study of pneumococcal conjugate vaccine with nine serotypes (PCV-9) used as its comparator an active vaccine [9]. Specifically, the PCV-9 was reconstituted with the DTP-Hib vaccine. The comparator was vaccine-diluent mixed with the same DTP-Hib vaccine. In another study, a novel, bivalent, heat-killed, whole-cell oral cholera vaccine is compared to a similarly manufactured, heat-killed Escherichia coli K12 vaccine-a vaccine of no therapeutic benefit [10]. In a third, recent study of a pneumococcal conjugate vaccine with seven stereotypes paired serially with a 23-valent, pneumococcal polysaccharide vaccine, the investigators used as the comparator hepatitis A or B vaccines [11]. In a fourth study, the study vaccine consisted of a Pseudomonas aeruginosa flagellar protein combined with aluminum hydroxide and thimerosal [12]. The comparator consisted of just aluminum hydroxide combined with thimerosal."

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831649/?tool=pubmed
 

"The use of tumorigenic and tumor-derived cells is a major safety concern due to the potential presence of viruses such as retroviruses and oncogenic (CANCER) DNA viruses that could be associated with tumorigencity (formation of tumors), Therefore, detection of persistent, latent (quiet) DNA viruses, and endogenous RETROVIRUSES (ex. AIDS is a slow replicating retrovirus) in vaccine cell substrates is important for vaccine safety, particularly in the development of live viral vaccines, where there are no or minimal virus inactivation and removal steps during vaccine manufacturing." 
 

http://www.fda.gov/biologicsbloodvaccines/scienceresearch/biologicsresearchareas/ucm127327.htm
 

 

“ However, since vaccine preparation involves the use of materials of biological origin, vaccines are subject to contamination by micro-organisms. In fact, vaccine contamination has occurred; a historical example of vaccine contamination, for example, can be found in the early days of development of the smallpox vaccine. The introduction of new techniques of vaccine virus production on cell cultures has lead to safer vaccines, but has not completely removed the risk of virus contamination. There are several examples of vaccine contamination, for example, contamination of human vaccines against poliomyelitis by SV40 virus from the use of monkey primary renal cells. Several veterinary vaccines have been contaminated by pestiviruses from foetal calf serum.These incidents have lead industry to change certain practices and regulatory authorities to develop more stringent and detailed requirements. But the increasing number of target species for vaccines, the diversity of the origin of biological materials and the extremely high number of known and unknown viruses and their constant evolution represent a challenge to vaccine producers and regulatory authorities.”

http://www.ncbi.nlm.nih.gov/pubmed/20456974
 

 

 

“We examined live virus vaccines against measles, mumps, and rubella for the presence of pestivirus RNA or of pestiviruses by reverse transcription PCR. Pestivirus RNA was detected in two measles-mumps-rubella combined vaccines and in two monovalent vaccines against mumps and rubella. Nucleotide sequence analysis of the PCR products indicated that a modified live vaccine strain used for immunization of cattle against bovine viral diarrhea is not responsible for the contamination of the vaccines.” (something else inside them is...)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC264050/

 

“The novel human retrovirus xenotropic murine leukemia virus-related virus (XMRV) is arguably the most controversial virus of this moment. After its original discovery in prostate cancer tissue from North American patients, it was subsequently detected in individuals with chronic fatigue syndrome from the same continent. However, most other research groups, mainly from Europe, reported negative results. The positive results could possibly be attributed to contamination with mouse products in a number of cases, as XMRV is nearly identical in nucleotide sequence to endogenous retroviruses in the mouse genome. But the detection of integrated XMRV proviruses in prostate cancer tissue proves it to be a genuine virus that replicates in human cells, leaving the question: how did XMRV enter the human population? We will discuss two possible routes: either via direct virus transmission from mouse to human, as repeatedly seen for, e.g., Hantaviruses, or via the use of mouse-related products by humans, including vaccines. We hypothesize that mouse cells or human cell lines used for vaccine production could have been contaminated with a replicating variant of the XMRV precursors encoded by the mouse genome.”

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109487/

 

“This overview describes the problems and risks associated with viral contaminations in animal cell culture, describes the origins of these contaminations as well as the most important viruses associated with viral contaminations in cell culture.” (cell cultures used in vaccines)

“contaminations are a serious threat for animal cell cultures and may lead to false results in research, development, and virus screening, to viral contaminations in the biologicals derived from the contaminated cultures and finally to an infection of the treated patient.”

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463984/ 

 

 

“Current U.S. requirements for testing cell substrates used in production of human biological products (*VACCINES*) for contamination with bovine and porcine viruses are U.S. Department of Agriculture (USDA) 9CFR tests for bovine serum or porcine trypsin. 9CFR requires testing of bovine serum for seven specific viruses in six families (immunofluorescence) and at least 2 additional families non-specifically (cytopathicity and hemadsorption). 9CFR testing of porcine trypsin is for porcine parvovirus. Recent contaminations suggest these tests may not be sufficient. Assay sensitivity was not the issue for these contaminations that were caused by viruses/virus families not represented in the 9CFR screen. A detailed literature search was undertaken to determine which viruses that infect cattle or swine or bovine or porcine cells in culture also have human host range [ability to infect humans or human cells in culture] and to predict their detection by the currently used 9CFR procedures. There are more viruses of potential risk to biological products manufactured using bovine or porcine raw materials than are likely to be detected by 9CFR testing procedures; even within families, not all members would necessarily be detected....Cell-culture derived vaccines for human use were developed in the 1950’s. Since fetal calf serum and bovine or porcine trypsin were used in cell culture, the 9CFR tests developed for veterinary use to screen for viruses that can infect cattle and swine were implemented by the authorities regulating human vaccines. However, many viruses not of significant concern to the cattle and swine industry are not addressed by the 9CFR testing. Today, over half a century after cell culture-derived vaccines were initially developed, the human biologics industry is still using the methods specified in the 9CFR regulations for testing FBS and porcine trypsin.” OCT 2011

 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206158/ 

 

“vaccines are not standard from one batch to the next. 3. Unless the vaccine is properly prepared and refrigerated, its potency and reactivity varies with shelf life. In fact, the whole question of vaccine detoxification has never been systematically investigated. Listed in order of increasing severity, observed adverse reactions include irritability, persistent, unusually high pitched crying, somnolence, seizures, a shock-like "hypotensive, hyporesponsive" state, and an encephalopathy. Since the neurologic picture is not specific for pertussis vaccination, its temporal relationship to the vaccination is the critical variable for determining causation."

 

http://www.ncbi.nlm.nih.gov/pubmed/1981251

 

{Remember SV 40 is found in cancer patients}
"Mycoplasmas in frozen bovine serum were effectively inactivated by gamma-irradiation at 25-40 kGy. The larger viruses tested, respiratory enteric orphan (REO) and Cache Valley virus (CVV), were inactivated completely, while the smaller virus, simian virus type 40, was not inactivated. Gamma-irradiation of bovine-sourced serum is therefore useful for mitigating the risk of introduction of mycoplasmas and many of the viral contaminants found in biologics unprocessed bulk (e.g., CVV, REO virus, epizootic hemorrhagic disease virus). This mitigation strategy is not useful for the smaller viruses (e.g., polyomaviruses, parvoviruses, picornaviruses, caliciviruses)." 2010

 

http://www.ncbi.nlm.nih.gov/pubmed/21502047

 

"All currently licensed yellow fever (YF) vaccines are propagated in chicken embryos. Recent studies of chick cell-derived measles and mumps vaccines show evidence of two types of retrovirus particles, the endogenous avian retrovirus (EAV) and the endogenous avian leukosis virus (ALV-E), which originate from the chicken embryonic fibroblast substrates. In this study, we investigated substrate-derived avian retrovirus contamination in YF vaccines currently produced by three manufacturers (YF-vax [Connaught Laboratories], Stamaril [Aventis], and YF-FIOCRUZ [FIOCRUZ-Bio-Manguinhos]). Testing for reverse transcriptase (RT) activity was not possible because of assay inhibition. However, Western blot analysis of virus pellets with anti-ALV RT antiserum detected three distinct RT proteins in all vaccines, indicating that more than one source is responsible for the RTs present in the vaccines."

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC140796/
 

 

" In young children, a highly significant correlation exists between the number of pediatric aluminum-adjuvanted vaccines administered and the rate of autism spectrum disorders. Many of the features of aluminum-induced neurotoxicity may arise, in part, from autoimmune reactions, as part of the ASIA syndrome."

 

http://www.ncbi.nlm.nih.gov/pubmed/23609067

 

 

"We describe a form of the autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA syndrome) in commercial sheep, linked to the repetitive inoculation of aluminum-containing adjuvants through vaccination. The syndrome shows an acute phase that affects less than 0.5% of animals in a given herd, it appears 2-6 days after an adjuvant-containing inoculation and it is characterized by an acute neurological episode with low response to external stimuli and acute meningoencephalitis, most animals apparently recovering afterward. The chronic phase is seen in a higher proportion of flocks, it can follow the acute phase, and it is triggered by external stimuli, mostly low temperatures. The chronic phase begins with an excitatory phase, followed by weakness, extreme cachexia, tetraplegia and death. Gross lesions are related to a cachectic process with muscular atrophy, and microscopic lesions are mostly linked to a neurodegenerative process in both dorsal and ventral column of the gray matter of the spinal cord. Experimental reproduction of ovine ASIA in a small group of repeatedly vaccinated animals was successful. Detection of Al(III) in tissues indicated the presence of aluminum in the nervous tissue of experimental animals. The present report is the first description of a new sheep syndrome (ovine ASIA syndrome) linked to multiple, repetitive vaccination and that can have devastating consequences as it happened after the compulsory vaccination against bluetongue in 2008. The ovine ASIA syndrome can be used as a model of other similar diseases affecting both human and animals. A major research effort is needed in order to understand its complex pathogenesis." 2013



http://www.ncbi.nlm.nih.gov/pubmed/23579772

 

Our findings indicate that vaccinal immunity might facilitate an evolutional event through antigenic selection,

genetic mutation among virulent virus populations shed from vaccinated flocks,

or both.”
 

http://www.ncbi.nlm.nih.gov/pubmed/24689191

 

 

Nonfebrile seizures after mumps, measles, rubella, and varicella-zoster virus combination vaccination with detection of measles virus RNA in serum, throat, and urine.

"We report the case of a child presenting with nonfebrile seizures 6 and 13 days after the first vaccination with a measles, mumps, rubella, and varicella (MMRV) combination vaccine. Measles virus RNA was detected in the patient's serum, throat, and urine. Genotyping revealed the Schwarz vaccine virus strain.

An 11-month-old boy was presented to the pediatric unit after experiencing three seizures in the morning of the same day. The seizures were initiated by a sharp outcry with symmetric tonic-clonic movement of the arms and legs. During the seizures, the child was not reacting to his mother and had cyanotic lips. Seizures stopped spontaneously, without the administration of anticonvulsants, after approximately 1 to 2 min. Immediately after the seizures, body temperature, as measured by the mother as well as by the emergency physician, was not elevated (37.3°C). Upon admission, the child was sleepy but conscious and without signs of meningitis. The child had a slight rash on his trunk and pale skin color; otherwise, the clinical examination was unremarkable.

There was no history of seizures before or any other known medical conditions. Six days before the seizure, the first vaccination with the regular measles, mumps, rubella, and varicella (MMRV) vaccine (Priorix-Tetra; GlaxoSmithKline) was performed. In the meantime, there were no signs of infection or fever.

Viral concentration was low in serum and urine but remarkably higher in the throat swab."
"Even though live attenuated measles vaccines have been used for more than 40 years, data are scarce on the extent to which vaccine virus replicates in or is shed by vaccinees (5). Isolation of infectious vaccine virus from the blood and pharynx of vaccinated children by propagation on canine renal cell culture was successfully performed in early studies with the Edmonston strain (9), from experimentally vaccinated Cynomolgus monkeys after vaccination with the Schwarz vaccine strain (10), and in a study evaluating fever and rash appearing 3 to 9 days after measles vaccination (11)." 2013

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697452/



"We describe a death in a 15-mo-old girl who developed a varicella-like rash 20 d after varicella vaccination that lasted for 2 mo despite
acyclovir treatment. The rash was confirmed to be due to vaccine-strain varicella-zoster virus (VZV). This is the first case of fatal varicella
due to vaccine-strain VZV reported from the United States. The patient developed severe respiratory complications that worsened with each new
crop of varicella lesions; vaccine-strain VZV was detected in the bronchial lavage specimen. Sepsis and multi-organ failure led to death.
The patient did not have a previously diagnosed primary immune deficiency, but her failure to thrive and repeated hospitalizations early in life
(starting at 5 mo) for presumed infections and respiratory compromise treated with corticosteroids were suggestive of a primary or acquired immune
 deficiency. Providers should monitor for adverse reactions after varicella vaccination. If severe adverse events develop, acyclovir should be
administered as soon as possible. The possibility of acyclovir resistance and use of foscarnet should be considered if lesions do not improve
after 10 d of treatment (or if they become atypical [e.g., verrucous])." 2014

http://www.ncbi.nlm.nih.gov/pubmed/23982221



"We report the occurrence of one fatal case of the encephalitis associated with measles-rubella (MR) vaccine during an immunization campaign in São Paulo, Brazil. A 31 year-old-man, previously in good health, was admitted at emergency room, with confusion, agitation, inability to stand and hold his head up. Ten days prior to admission, he was vaccinated with combined MR vaccine (Serum Institute of India) and three days later he developed 'flu-like' illness with fever, myalgia and headache. Results of clinical and laboratory exams were consistent with a pattern of viral encephalitis. During hospitalization, his condition deteriorated rapidly with tetraplegia and progression to coma. On the 3rd day of hospitalization he died. Histopathology confirmed encephalitis and immunohistochemistry was positive for RV on brain tissue. RV was also detected by qPCR and virus isolation in cerebrospinal fluid, brain and other clinical samples. The sequence obtained from the isolated virus was identical to that of the RA 27/3 vaccine strain."  2013

http://www.ncbi.nlm.nih.gov/pubmed/24216323



"We report the first laboratory-documented case of herpes zoster caused by the attenuated varicella zoster virus (VZV) contained in Zostavax in a 68-year-old immunocompetent adult with strong evidence of prior wild-type VZV infection." APR 2014

http://www.ncbi.nlm.nih.gov/pubmed/24470276



"we describe a previously immunized child who developed herpes zoster with meningitis. Vaccine strain of VZV was recovered from a skin swab and the cerebrospinal fluid. Reactivation of the vaccine strain of VZV should be recognized as a potential cause of meningitis in children." 2011

http://www.ncbi.nlm.nih.gov/pubmed/20844461

 

 

A 44-year old man was admitted to our hospital with edema in his face and legs and cervical lymphadenopathy which occurred 18 days after influenza vaccine (Agrippal®, Novartis). The laboratory showed: creatinine 44mg/l, urea 106mg/dl. In the urinalysis was evident: proteinuria 4g/24h and hyaline casts. Serological test (ANA, DNA, ANCAp, ANCAc, C3, C4, HBsAg, HCV and HIV)  were negative. Renal biopsy was performed. Light microscopy showed evidence of severe acute tubular injury (Figure 1 A) and a moderate, diffuse interstitial inflammatory infiltrate consisting of mononuclear cells and severe edema.


PDF Download:

http://www.revistanefrologia.com/revistas/P1-E536/P1-E536-S3514-A11370-EN.pdf

Rhabdomyolysis secondary to influenza A H1N1 vaccine resulting in acute kidney injury.

This is a rare side effect of influenza A H1N1 vaccine. Physicians should advise patients to seek medical care when muscle symptoms are present and consider the possibility of rhabdomyolysis due to vaccination. Trials are required to better define the incidence of this important side effect."

http://www.ncbi.nlm.nih.gov/pubmed/23218783

  

“Although seasonal and H1N1 vaccines are safe and effective (CONTRADICTION), they also have the potential to induce autoantibodies in selected AIRD patients AND HEALTHY ADULTS. Follow-up of such individuals is proposed and further research is needed.”

 

http://www.ncbi.nlm.nih.gov/pubmed/22235050



"The neurotoxic organomercurial thimerosal (THIM), used for decades as vaccine preservative, is a suspected factor in the pathogenesis of some neurodevelopmental disorders. Previously we showed that neonatal administration of THIM at doses equivalent to those used in infant vaccines or higher, causes lasting alterations in the brain opioid system in rats.

Here we investigated neonatal treatment with THIM (at doses 12, 240, 1440 and 3000 μg Hg/kg) on behaviors, which are characteristically altered in AUTISM, such as locomotor activity, anxiety, social interactions, spatial learning, and on the brain dopaminergic system in Wistar rats of both sexes. Adult male and female rats, which were exposed to the entire range of THIM doses during the early postnatal life, manifested impairments of locomotor activity and increased anxiety/neophobia in the open field test."
 

http://www.ncbi.nlm.nih.gov/pubmed/21549155

​Evidence for a Dysregulated Immune System in the Etiology of Psychiatric Disorders.

There is extensive bi-directional communication between the brain and the immune system in both health and disease. In recent years, the role of an altered immune system in the etiology of major psychiatric disorders has become more apparent. Studies have demonstrated that some patients with major psychiatric disorders exhibit characteristic signs of immune dysregulation and that this may be a common pathophysiological mechanism that underlies the development and progression of these disorders. Furthermore, many psychiatric disorders are also often accompanied by chronic medical conditions related to immune dysfunction such as autoimmune diseases, diabetes and atherosclerosis. One of the major psychiatric disorders that has been associated with an altered immune system is schizophrenia, with approximately one third of patients with this disorder showing immunological abnormalities such as an altered cytokine profile in serum and cerebrospinal fluid. An altered cytokine profile is also found in a proportion of patients with major depressive disorder and is thought to be potentially related to the pathophysiology of this disorder. Emerging evidence suggests that altered immune parameters may also be implicated in the neurobiological etiology of autism spectrum disorders. Further support for a role of immune dysregulation in the pathophysiology of these psychiatric disorders comes from studies showing the immunomodulating effects of antipsychotics and antidepressants, and the mood altering effects of anti-inflammatory therapies. This review will not attempt to discuss all of the psychiatric disorders that have been associated with an augmented immune system, but will instead focus on several key disorders where dysregulation of this system has been implicated in their pathophysiology including depression, schizophrenia and autism spectrum disorder.

http://www.ncbi.nlm.nih.gov/pubmed/23645137


Subacute thyroiditis and dyserythropoesis after influenza vaccination suggesting immune dysregulation

We propose that, the events occurring in the patient may be explained as result of complex interactions between the individual genetic background and environmental exposure to infectious agents that generated a pro-inflammatory status, where the vaccine was the trigger for the subsequent alterations in thyroid and bone marrow. These findings highlight the importance of immunogenetic factors involved in response to vaccination that is the central theme in the growing field of 'vaccinomics' 2011

http://www.ncbi.nlm.nih.gov/pubmed/22111471

 

An emergent poxvirus from humans and cattle in Rio de Janeiro State: Cantagalo virus may derive from Brazilian smallpox vaccine.
 

“The biological properties of poxvirus isolates from skin lesions on dairy cows and milkers during recent exanthem episodes in Cantagalo County, Rio de Janeiro State, Brazil, were more like vaccinia virus (VV) than cowpox virus. PCR amplification of the hemagglutinin (HA) gene substantiated the isolate classification as an Old World orthopoxvirus, and alignment of the HA sequences with those of other orthopoxviruses indicated that all the isolates represented a single strain of VV, which we have designated Cantagalo virus (CTGV). HA sequences of the Brazilian smallpox vaccine strain (VV-IOC), used over 20 years ago, and CTGV showed 98.2% identity; phylogeny inference of CTGV, VV-IOC, and 12 VV strains placed VV-IOC and CTGV together in a distinct clade. Viral DNA restriction patterns and protein profiles showed a few differences between VV-IOC and CTGV. Together, the data suggested that CTGV may have derived from VV-IOC by persisting in an indigenous animal(s), accumulating polymorphisms, and now emerging in cattle and milkers as CTGV. CTGV may represent the first case of long-term persistence of vaccinia in the New World.”

http://www.ncbi.nlm.nih.gov/pubmed/11080491

 

 

"Similarly, vaccination is depicted as playing an important role in CFS onset. Recently, a case report pointed toward a causal association between silicone breast linkage, hepatitis B virus vaccination, and CFS onset in a previous healthy woman. Such findings suggest that there is a likely deregulation of the immune system influenced by specific agents (infections, vaccination, and products, such as silicone). Evidence suggests that CFS is a complex disease in which several risk factors might interact to cause its full expression. Thus, although different alterations have been found in CFS patients, undoubtedly the main feature is central nervous system involvement with immunological alterations. Therefore, a new term neuro-psycho-immunology must be quoted. New studies based on this concept are needed in order to investigate syndromes, such as CFS, in which immunological alterations are thought to be associated with concomitant psychological and health disturbances."

http://www.ncbi.nlm.nih.gov/pubmed/19758205

 

"Persistence of the Rubella vaccine virus was also demonstrated in granuloma lesions sampled 4 to 5 years earlier. The persistence of rubella virus vaccine strain in three out of three consecutive cutaneous granuloma patients with PID strongly suggests a causal association between RV and granuloma in this setting." Jan 2014

 

http://www.ncbi.nlm.nih.gov/pubmed/24476349

 


The language in the National Childhood Vaccine Injury Act of 1986 which specifically refers to vaccines as "unavoidably unsafe"(check 'comment k' of the Vaccine Act of 1986) Which the U.S. Supreme Court then decided, 22 Feb 2011 (6-2), to interpret as meaning vaccine manufacturers have immunity from all civil liability, regardless of whether avoidably or unavoidably unsafe - Bruesewitz v. Wyeth LLC, No. 09-152

“The Committee has set forth Comment K in this bill because it intends that the principle in Comment K regarding ‘unavoidably unsafe’ products, I.e., those products which in the present state of human skill and knowledge cannot be made safe, apply to the vaccines covered in the bill and that such products not be the subject of liability in the tort system.”

 

Id. , at 25–26.


http://www.law.cornell.edu/supct/html/09-152.ZD.htm

l“ i.e., those products which in the present state of human skill and knowledge cannot be made safe,”

now, take out the explanation of unavoidably unsafe and here is what you get


“The Committee has set forth Comment K in this bill because it intends that the principle in Comment K regarding ‘unavoidably unsafe’ products,... apply to the vaccines covered in the bill and that such products not be the subject of liability in the tort system.” Id. , at 25–26.

 

http://www.law.cornell.edu/supct/html/09-152.ZD.html

 

 

Simultaneous sudden infant death syndrome.

"The simultaneous sudden deaths of twins rarely occur and therefore it has received limited attention in the medical literature. When the deaths of the twins meet the defined criteria for sudden infant death syndrome (SIDS) independently and take place within the same 24 h range it can be called as simultaneous SIDS (SSIDS). The case(s): Twin girls (3.5-month-old) were found dead by their mother in their crib, both in supine position. The infants were identical twins and delivered at a hospital by cesarean section. Both infants were healthy and did not have any serious medical history. Two days prior to the incident, the twins had received the second dose of oral polio, DPT and the first dose of hepatitis B vaccines and they had fever on the first day of the vaccination and been given teaspoonful of acetaminophen. Death scene investigation, judicial investigation, parental assessment, macroscopic and microscopic autopsy findings and the toxicological analysis did not yield any specific cause of death. The case(s) were referred to a supreme board composed of multidisciplinary medical professionals at the Institute of Forensic Medicine, Ministry of Justice, in Istanbul. The Board decided that the available data was consistent with SIDS. These SIDS case(s) are presented because twin SIDS are rare and this is the first time that a simultaneous twin SIDS have been reported in Turkey. Simultaneous SIDS cases have many implications regarding definition, diagnosis and medico-legal approach." 2007
 

http://www.ncbi.nlm.nih.gov/pubmed/17654772 

 

“ Additionally, a baboon endogenous virus strain M7 was detected, likely due to the monkey cell line in which RotaTeq was produced from.”

 

“ The sample of RotaTeq vaccine tested positive for rotavirus A and baboon endogenous virus, as previously reported by Victoria and colleagues [17]. The origin of the baboon endogenous virus is assumed to be related to the African green monkey-derived Vero cell line used in its manufacture and cross-hybridization of its endogenous retroviruses to the baboon endogenous retrovirus probes [17].

 

Microarray analysis did not detect PCV from the RotaTeq vaccine, which confirmed the previous results from Victoria et al. that LLMDA detected PCV from Rotarix but did not detect PCV from the RotaTeq vaccine [17]. However, PCV2 in RotaTeq vaccine was detected by PCR assays. RotaTeq contained small PCV-1 and PCV-2 genome fragments but did not contain detectable larger portions of PCV genomes [30]. Studies have shown that the amount of PCV in RotaTeq was about 4000 times lower than the PCV in Rotarix, with the PCV in RotaTeq being barely detectable [25, 31, 32]. A case study by Ranucci et al. has reported that the concentration of PCV-2 DNA fragment in clinical consistency lots was in the range of below limit of detection to 6.4 × 103 copies/mL when measured by QPCR, and that PCV1 was below limit of detection (0.1–0.8 × 103 copies/mL) [30]. ” 2014

 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980782/


"More than 8 years after varicella vaccination, a healthy 16 year-old boy presented with keratouveitis, severe inflammatory glaucoma in his left eye, and Hutchinson's sign. He was treated with systemic acyclovir, topical steroids, cycloplegics, and glaucoma medications for a full recovery two months after presentation. It is unclear whether the source of herpes zoster which reactivated in this patient represents wild type virus or his previous vaccine strain. Herpes zoster ophthalmicus is very rare in the pediatric population after varicella vaccination but can cause severe inflammatory glaucoma that requires aggressive therapy."

 

http://www.ncbi.nlm.nih.gov/pubmed/19294571

 

"A five-year-old girl, vaccinated against varicella-zoster virus (VZV) presented with clinical symptoms of herpes zoster in the 6th cervical dermatome. A VZV direct immune-fluorescence assay was negative three times but additional genotypical analysis showed a VZV strain genotype 2 (Oka vaccine strain). Therefore the diagnosis of a breakthrough varicella disease with the vaccine strain was established. An immunodeficiency was ruled out and the patient responded well to the initiated therapy. This case demonstrates that a negative VZV direct immunofluorescence assay does not exclude an infection with the vaccine strain." 2013

 

http://www.ncbi.nlm.nih.gov/pubmed/23358727


"A 23-year-old teacher presented to hospital with a mild case of varicella. VZV vaccine strain vOka that resembles Varilrix but not Varivax or Biken strains was isolated from the skin lesion of the patient and was identified by single nucleotide polymorphism (SNP) analysis. The teacher denied having varicella vaccine before. Retrospective analysis suggests the transmission came from a pupil who developed zoster 13 months after varicella vaccine Varilrix."

 

http://www.ncbi.nlm.nih.gov/pubmed/21134454


"A 25-day-old infant developed varicella 22 days after her mother received varicella vaccine postpartum. Infection with vaccine-strain varicella-zoster virus was confirmed by genetic analysis. The mother had no postvaccination rash nor did other contacts have rash or recent vaccination." 2012

 

http://www.ncbi.nlm.nih.gov/pubmed/22572750

 


"A 12-year-old boy developed a skin rash following administration of MMR varicella zoster virus vaccine [route, dosage and outcome not stated].

The boy's medical history included DiGeorge syndrome and juvenile idiopathic arthritis, which was treated with etanercept. He inadvertently received the MMR varicella zoster virus vaccine during a well-child visit. Ten days later, he was hospitalised with a 2-day history of fever, conjunctivitis, rash and sore throat. His mother held further doses of etanercept. Upon admission, physical examination revealed a blanching morbilliform rash on his face, ears, neck, chest, back and limbs. He also had mild conjunctivitis, palatal petechiae with posterior pharyngeal erythema and mild post auricular cervical lymphadenopathy.

The boy began receiving aciclovir. Urine and skin samples were positive for measles virus, and were phylogenetically clustered as genotype A with Edmonston reference strain. He was diagnosed with vaccine-associated disease." 2014

 

-Pediatric Infectious Disease Journal 33: 117, No. 1, Jan 2014 - USA
http://link.springer.com/article/10.1007/s40278-014-0119-z

 

“An outbreak of nine cases of mumps was reported from a total of 97 vaccinated nursing students at two medical colleges in Thailand in 2010, 16-26 days after administration of MMR vaccine containing the L-Zagreb mumps strain......This study provides another virologically confirmed example of mumps resulting from the L-Zagreb vaccine strain.” 2013

 

http://www.ncbi.nlm.nih.gov/pubmed/23089079

 

 

"Healthcare workers born after 1980 were 20 times (95% CI: 11.0 to 37.2) more likely to be susceptible to measles, and 2 times (95% CI: 1.2 to 3.2) more likely to be susceptible to varicella than those those born before 1965.

CONCLUSIONS:The susceptibility to measles in healthcare workers in our centre is higher in younger cohorts, with values higher than expected in a community with high vaccination coverage against measles, mumps, rubella vaccine (MMR) in the paediatric population for many years." 2012

 

http://www.ncbi.nlm.nih.gov/pubmed/22137370

 

"The US childhood immunization schedule requires

26 vaccine doses for infants aged less than 1 year,

THE MOST IN THE WORLD, yet 33 nations have better Infant

Mortality Rates (IMR). Using linear regression, the

immunization schedules of these 34 nations were examined

and a correlation coefficient of 0.70 (p < 0.0001) was found

between infant mortality rates and the number of vaccine

doses routinely given to infants. When nations were grouped

into five different vaccine dose ranges (12–14, 15–17, 18–20,

21–23, and 24–26), 98.3% of the total variance in IMR was

explained by the unweighted linear regression model.

These findings demonstrate a counter-intuitive relationship:
nations that require more vaccine doses tend
to have higher infant mortality rates.

Efforts to reduce the relatively high UNITED STATES INFANT

MORTALITY RATE have been elusive. Finding ways to lower

preterm birth rates should be a high priority. However,

preventing premature births is just a partial solution to reduce

infant deaths. A closer inspection of correlations between vaccine doses, biochemical or synergistic toxicity, and IMRs, is essential. All nations—rich and poor, advanced and developing—have an obligation to determine whether their immunization schedules are achieving their desired goals."
 

 scientific study can be seen here with all models
http://het.sagepub.com/content/early/2011/05/04/0960327111407644.full.pdf+htm

Share