Full Text Studies/Downloads

Autoimmune hazards of Hepatitis B vaccine


{This is what they give to your newborn in the first 24 hrs of life. An STD vaccine. You have the RIGHT to say NO, you have a right to say wait until my child is 2 yrs old.}


"Strangely enough, for cost-effective as it is, the pharmaceutical sector of vaccine development

remains far from the elementary requirements of evidence-based medicine (EBM) [1]. Whereas

personal experience suggested that editors, even in leading medical journal, show a regrettable

selectivity in publishing papers on this topics, this has been clearlyconfirmed by the huge delay

between the preliminary publication of Hernan’s et al. results on the neurological hazards of hepatitis

B vaccine (HBV) [2] and their final paper [3] while in the meantime, other investigations of the same

team were published and given media coverage without apparent difficulty as they gave good

arguments favouring vaccine safety [4]; in parallel, a number of papers of problematic relevance were

published to support the safety of HBV vaccine. . . .


Another example: whereas for any person with a minimum of medical awareness, the auto-immune

risk of vaccination (and, even more, of multiple vaccinations) seems obvious, it is rather strange that

the classical duration of safety studies from vaccine development does not go beyond 4 days on

average, as performing the majority of clinical trials in high endemic countries does not optimise the

guarantee of systematic long-term follow-up [1]. bTo be sure, vaccination is starting to emerge as a

more complex issue than previously considered [5]"


"According to Hippocratic tradition, the safety level of a preventive medicine must be very high, as it

is aimed at protecting people against diseases that they may not contract. This paper points out

that information on the safety of hepatitis B vaccine (HBV) is biased as compared to classical

requirements of evidence-based medicine (EBM), as exemplified by a documented selectivity in the

presentation or even publication of available clinical or epidemiological data. Then, a review is made

of data suggesting that HBV is remarkable by the frequency, the severity and the variety of its

complications, some of them probably related to a mechanism of molecular mimicry leading to

demyelinating diseases, and the others reproducing the spectrum of non-hepatic manifestations of

natural hepatitis B. To be explained, this unusual spectrum of toxicity requires additional investigations

based upon complete release of available data."









Autoimmunity induced by adjuvant hydrocarbon oil components of vaccine


"We have reported that a single intraperitoneal injection of the adjuvant oils pristane, IFA or squalene induces lupus-related autoantibodies to nRNP/Sm and -Su in non-autoimmune BALB/c mice. Induction of these autoantibodies appeared to be associated with the hydrocarbon’s ability to induce IL-12, IL-6, and TNF-a, suggesting a relationship with hydrocarbon’s adjuvanticity"


"Although there is no information regarding the duration of acceptable observation period, 1–3 months may not be long enough for the purpose, considering that it takes 2–6 months for adjuvant oils to induce lupus autoantibodies in mice and that the oil-induced granulomatous inflammation can last for years."


"An important factor to consider in vaccine-induced autoimmunity is the fact that vaccines contain a microbial component (or other type of antigens) and adjuvant [75]. Differentiating adverse reactions caused by these two factors is often difficult, or it can even be a result of the combination of both. Nevertheless, the microbial components are generally considered responsible for adverse reactions and minimum attention has been paid to the potential effects of the adjuvant component. Molecular mimicry of a microbial antigen in a vaccine and a host tissue self-antigen is often considered important [61]. Immune complexes also may be formed following vaccination [61,76], deposit in vascular endothelium and induce vasculitis. Induction of cytokines or shifting cytokine balance may also play an important role."


Yoshiki Kuroda a, Dina C. Nacionales a, Jun Akaogi a,Westley H. Reeves a,b, Minoru Satoh a,b,*
a Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, ARB-R2-156, 1600 SW Archer Road, P.O. Box 100221 Gainesville, FL 32610-0221, USA b Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610-0221, USA




Thimerosal-Derived Ethylmercury Is aMitochondrial Toxin in Human Astrocytes: Possible Role of Fenton Chemistry in the Oxidation and Breakage ofmtDNA


"The widespread use of Thimerosal exposes many to its potential toxic effects, especially in utero and in neonates. We report the results of a series of experiments using cultured normal human astrocytes (NHA) exposed to Thimerosal to study the compound’s effect on astrocyte


"It can be seen that low concentrations of ethylmercury cause an increase in both signals. The finding that ethylmercury increases ROS generation is not surprising, given the well-known effects this agent has in disrupting cellular thiol/glutathione-based antioxidant defenses  The hyperpolarization of mitochondrial membrane potential was unexpected, given that depolarization of mitochondria has been observed in most cell types prior to apoptosis. At higher concentrations (>7.2 μM Thimerosal) a loss of mitochondrial signal and of DCF is observed.

This loss of signal, when comparing >7.2 μM with <7.2 μM 4 Thimerosal, correlates well with changes in cell morphology, cell shrinkage and the formation of a ruffled plasma membrane and blebs. The fluorescence levels of all three panels are matched in the two images, so that the color levels absolutely reflect signal levels and show that Thimerosal causes an approximately 50% drop in mitochondrial membrane potential and a two-fold increase in ROS."


"We find that ethylmercury not only inhibits mitochondrial respiration leading to a drop in the steady state membrane potential, but also concurrent with these phenomena increases the formation of superoxide, hydrogen peroxide, and Fenton/Haber-Weiss generated hydroxyl radical. These oxidants increase the levels of cellular aldehyde/ketones. Additionally, we find a five-fold increase in the levels of oxidant damaged mitochondrial DNA bases and increases in the levels of mtDNA nicks and blunt-ended breaks. Highly damaged mitochondria are characterized by having very low membrane potentials, increased superoxide/hydrogen peroxide production, and extensively damaged mtDNA and proteins. These mitochondria appear to have undergone a permeability transition, an observation supported by the five-fold increase in Caspase-3 activity observed after Thimerosal treatment."



Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations 2012

"Aluminum (Al) is highly neurotoxic and has been shown to impair both prenatal and postnatal brain development in humans and experimental animals. In addition to its neurotoxic properties, Al is a potent stimulator of the immune system, which is the very reason why it is used as an adjuvant. Given this, it is somewhat surprising to find that in spite of over 80 years of use, the safety of Al adjuvants continues to rest on assumptions rather than scientific evidence. For example, nothing is known about the toxicology and pharmacokinetics of Al adjuvants in infants and children. On the other hand, in adult humans long-term persistence of Al vaccine adjuvants can lead to cognitive dysfunction and autoimmunity. Yet, in spite of these observations children continue regularly to be exposed to much higher levels of Al adjuvants than adults, via routine childhood vaccination programmes."






























"Immune challenges during early development, including those vaccine-induced, can lead to permanent detrimental alterations of the brain and immune function. Experimental evidence also shows that simultaneous administration of as little as two to three immune adjuvants can overcome genetic resistance to autoimmunity. In some developed countries, by the time children are 4 to 6 years old, they will have received a total of 126 antigenic compounds along with high amounts of aluminum (Al) adjuvants through routine vaccinations. According to the US Food and Drug Administration, safety assessments for vaccines have often not included appropriate toxicity studies because vaccines have not been viewed as inherently toxic. Taken together, these observations raise plausible concerns about the overall safety of current childhood vaccination programs. When assessing adjuvant toxicity in children, several key points ought to be considered: (i) infants and children should not be viewed as ‘‘small adults’’ with regard to toxicological risk as their unique physiology makes them much more vulnerable to toxic insults; (ii) in adult humans Al vaccine adjuvants have been linked to a variety of serious autoimmune and inflammatory conditions (i.e., ‘‘ASIA’’), yet children are regularly exposed to much higher amounts of Al from vaccines than adults; (iii) it is often assumed that peripheral immune responses do not affect brain function. However, it is now clearly established that there is a bidirectional neuro-immune cross-talk that plays crucial roles in immunoregulation as well as brain function. In turn, perturbations of the neuro-immune axis have been demonstrated in many autoimmune diseases encompassed in ‘‘ASIA’’ and are thought to be driven by a hyperactive immune response; and (iv) the same components of the neuroimmune axis that play key roles in brain development and immune function are heavily targeted by Al adjuvants. In summary, research evidence shows that increasing concerns about current vaccination practices may indeed be warranted. Because children may be most at risk of vaccine-induced complications, a rigorous evaluation of the vaccine-related adverse health impacts in the pediatric population is urgently needed."










Death after Quadrivalent Human Papillomavirus (HPV) Vaccination: Causal or Coincidental?


"Our study suggests that HPV vaccines containing HPV-16L1 antigens pose an inherent risk for triggering potentially fatal autoimmune vasculopathies.

Cerebral vasculitis is a serious disease which typically results in fatal outcomes when undiagnosed and left untreated. The fact that many of the symptoms reported to vaccine safety surveillance databases following HPV vaccination are indicative of cerebral vasculitis, but are unrecognized as such (i.e., intense persistent migraines, syncope, seizures, tremors and tingling, myalgia, locomotor abnormalities, psychotic symptoms and cognitive deficits), is a serious concern in light of the present findings. It thus appears that in some cases vaccination may be the triggering factor of fatal autoimmune/neurological events. Physicians should be aware of this association."








Influenza Vaccination During Pregnancy: A Critical Assessment of the Recommendations of the Advisory Committee on Immunization Practices (ACIP) Journal of American Physicians and Surgeons Volume 11 Number 2

"Influenza vaccination during all trimesters of pregnancy is now universally recommended in the United States. We critically reviewed the influenza vaccination policy of the CDC.s Advisory Committee on Immunization Practice (ACIP) and the citations that were used to support their recommendations. The ACIP.s citations and the current literature indicate that influenza infection is rarely a threat to a normal pregnancy. There is no convincing evidence of the effectiveness of influenza vaccination during this critical period. No studies have adequately assessed the risk of influenza vaccination during pregnancy, and animal safety testing is lacking. Thimerosal, a mercury-based preservative present in most inactivated formulations of the vaccine, has been implicated in human neurodevelopment disorders, including autism, and a broad range of animal and experimental reproductive toxicities including teratogenicity, mutagenicity, and fetal death. Thimerosal is classified as a human teratogen.The ACIP policy recommendation of routinely administering influenza vaccine during pregnancy is ill-advised and unsupported by current scientific literature, and it should be withdrawn. Use of thimerosal during pregnancy should be contraindicated."