Vaccinations
affect natural
immunity.

 


"Although persons often use vaccination and

immunization interchangeably in reference to active

immunization (VACCINES), the terms are

not synonomous because the administration of an

immunobiologic CANNOT be automatically equated

with the development of adequate immunity."

 

http://www.cdc.gov/mmwr/PDF/rr/rr4301.pdf  

 


Annual influenza vaccination affects the development of heterosubtypic immunity. 2012


Annual vaccination of healthy children >6 months of age against seasonal influenza has been recommended by public health authorities of some countries. However, currently used seasonal vaccines provide only limited protection against (potentially) pandemic influenza viruses. Furthermore, we recently hypothesized that annual vaccination may hamper the development of cross-reactive immunity against influenza A viruses of novel subtypes, that would otherwise be induced by natural infection. Here we summarize our findings in animal models in which we demonstrated that vaccination against influenza A/H3N2 virus reduced the induction of heterosubtypic immunity against highly pathogenic avian influenza A/H5N1 virus, otherwise induced by a prior infection with influenza A/H3N2 virus. The reduction of heterosubtypic immunity correlated with reduced virus-specific CD8+ T cell responses. An additional study was performed in humans, in which we collected peripheral blood mononuclear cells from annually vaccinated children with cystic fibrosis (CF) and age-matched unvaccinated healthy control children to study the virus-specific T cell response. An age-related increase of the virus-specific CD8+ T cell response was observed in unvaccinated children that was absent in vaccinated children with CF. These findings highlight the importance of the development of vaccines that provide protection against influenza A viruses of all subtypes.         (of course the answer is MORE and BETTER vaccines)


http://www.ncbi.nlm.nih.gov/pubmed/22643217  

 

 

"Thus, we conclude that aP (whooping cough) vaccination interferes with the optimal clearance of B. parapertussis and *enhances the *performance of this *pathogen. Our data raise the possibility that *widespread aP vaccination *can *create *hosts *more *susceptible to B. parapertussis infection."                                                                                                                                     http://www.ncbi.nlm.nih.gov/pubmed/20200027

 

"The combined measles, mumps, and rubella (MMR) vaccine has been successfully administered for >20 years. Because of this, protection by maternal antibodies in infants born to vaccinated mothers might be negatively affected.

Conclusions. “Children of mothers vaccinated against measles and, possibly, rubella have lower concentrations of maternal antibodies and lose protection by maternal antibodies at an earlier age than children of mothers in communities that oppose vaccination. This increases the risk of disease transmission in highly vaccinated populations. "


http://www.ncbi.nlm.nih.gov/pubmed/23661802


http://jid.oxfordjournals.org/content/early/2013/04/29/infdis.jit143.full

 

​"Varicella vaccination is less effective than the natural immunity that existed in prevaccine communities. Universal varicella vaccination has not proven to be cost-effective as increased HZ (Herpes Zoster {Shingles increased because of vaccine}) morbidity has disproportionately offset cost savings associated with reductions in varicella disease. Universal varicella vaccination has failed to provide long-term protection from VZV disease." 2013 PMID: 20642419


http://www.ncbi.nlm.nih.gov/pubmed/22659447

 

 

 

Vaccines create more powerful strains of bacteria and viruses. Superbugs.


"Vaccination against 2 avian viruses, the Marek disease virus, and the infectious bursal disease virus, were associated with the emergence of more virulent strains (33). An important role of host immunity in selecting for virulence is also suggested by the co-evolution of the myxomatosis virus and rabbits (34). Furthermore, immune pressure was shown to select for more virulent Plasmodium chabaudi parasites in mice (35). Based on mathematical modeling, vaccines designed to reduce pathogen growth rate and/or toxicity may result in the evolution of pathogens with higher levels of virulence."


http://wwwnc.cdc.gov/eid/article/15/8/08-1511_article.htm

"Hib immunization contributed to an increased risk for H. influenzae type a meningitis through selection of circulating H. influenzae type a clones." " the incidence for H. influenzae type A meningitis increased 8-fold"


http://jid.oxfordjournals.org/content/187/1/109.full.pdf+html


"Together, our data suggest that the high level of vaccine failure in Nicaraguan is probably not due to antigenic drift of commonly circulating virus strains nor the emergence of new antigenetically distinct virus strains. Furthermore, our data suggest that the widespread use of the RotaTeq vaccine has led to the introduction of vaccine genes into circulating human RotaViruses" Infect Genet Evol. 2012 Aug;12
 

http://www.ncbi.nlm.nih.gov/pubmed/22487061

 

"Furthermore, while India has been polio-free for a year, there has been a huge increase in non-polio acute flaccid paralysis (NPAFP). In 2011, there were an extra 47,500 new cases of NPAFP. Clinically indistinguishable from polio paralysis but twice as deadly, the incidence of NPAFP was directly proportional to doses of oral polio received. Though this data was collected within the polio surveillance system, it was not investigated."

http://www.ncbi.nlm.nih.gov/pubmed/22591873

 

"We present evidence that in the Netherlands the dramatic increase in pertussis is temporally associated with the emergence of Bordetella pertussis strains carrying a novel allele for the pertussis toxin promoter, which confers increased pertussis toxin (ptx) production. Epidemiologic data suggest that these strains are more virulent in humans."

 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815961/

 

 

An emergent poxvirus from humans and cattle in Rio de Janeiro State: Cantagalo virus may derive from Brazilian smallpox vaccine.

 

“The biological properties of poxvirus isolates from skin lesions on dairy cows and milkers during recent exanthem episodes in Cantagalo County, Rio de Janeiro State, Brazil, were more like vaccinia virus (VV) than cowpox virus. PCR amplification of the hemagglutinin (HA) gene substantiated the isolate classification as an Old World orthopoxvirus, and alignment of the HA sequences with those of other orthopoxviruses indicated that all the isolates represented a single strain of VV, which we have designated Cantagalo virus (CTGV). HA sequences of the Brazilian smallpox vaccine strain (VV-IOC), used over 20 years ago, and CTGV showed 98.2% identity; phylogeny inference of CTGV, VV-IOC, and 12 VV strains placed VV-IOC and CTGV together in a distinct clade. Viral DNA restriction patterns and protein profiles showed a few differences between VV-IOC and CTGV. Together, the data suggested that CTGV may have derived from VV-IOC by persisting in an indigenous animal(s), accumulating polymorphisms, and now emerging in cattle and milkers as CTGV. CTGV may represent the first case of long-term persistence of vaccinia in the New World.”

 

http://www.ncbi.nlm.nih.gov/pubmed/11080491

 

 

“Vaccines are not subject to double blind clinical trials despite the evidence of vaccine-drug interactions and perhaps also of vaccine-vaccine interactions.”“Where is the proof that vaccines are safe? The argument has never been that they are completely safe but that the consequences are less than having the disease. Now it is illustrated that the consequences of intensive vaccination schedules pose a greater risk than could ever have been imagined. This leads to the evolution of new viral strains, an unsurprising development when the environment to which it is exposed is being altered by new proteins, structural variants and ALTERED DNA.”

 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364648/

 

 

 

"Thus, we conclude that aP (whooping cough) vaccination interferes with the optimal clearance of B. parapertussis and *enhances the *performance of this *pathogen. Our data raise the possibility that *widespread aP vaccination *can *create *hosts *more *susceptible to B. parapertussis infection."                                                                                                                                     http://www.ncbi.nlm.nih.gov/pubmed/20200027

 

 

Vaccines create autoimmune disorders/complexes even in those who are not "genetically susceptible"


"Repeated immunization with antigen causes systemic autoimmunity in mice otherwise not prone to spontaneous autoimmune diseases. Overstimulation of CD4+ T cells led to the development of autoantibody-inducing CD4+ T (aiCD4+ T) cell which had undergone T cell receptor (TCR) revision and was capable of inducing autoantibodies." "Systemic autoimmunity appears to be the inevitable consequence of over-stimulating the host's immune ‘system’ by repeated immunization with antigen, to the levels that surpass system's self-organized criticality."


http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795160/

"Clustering of cases of insulin dependent diabetes (IDDM) occurring three years after hemophilus influenza B (HiB) immunization support causal relationship between immunization and IDDM (insulin dependent diabetes)."

http://www.ncbi.nlm.nih.gov/pubmed/12911277

​Immune complexes also may be formed following vaccination, deposit in vascular endothelium and induce vasculitis. Induction of cytokines or shifting cytokine balance may also play an important role."

http://www.ncbi.nlm.nih.gov/pubmed/15194169

 

 ​"We initiated and funded a collaborative study with Tuomilehto on the effect of the Haemophilus influenzae type b vaccine on type 1 diabetes and found that the data support a causal relation (paper submitted for publication). Furthermore, the potential risk of the vaccine exceeds the potential benefit. We compared a group that received four doses of the vaccine, a group that received one dose, and a group that was not vaccinated. The cumulative incidence of diabetes per 100000 in the three groups receiving four, one, and no doses of the vaccine was 261, 237, and 207 at age 7 and 398, 376, and 340 at age 10 respectively."

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1116914/

“Successful induction of antiphospholipid syndrome (APS) in two different non-autoimmune prone mouse strains, BALB/c and C57BL/6, was achieved by tetanus toxoid (TTd) hyperimmunization using different adjuvants (glycerol or aluminum hydroxide), and different adjuvant pretreatments (glycerol or Complete Freund's Adjuvant (CFA)). APS had different manifestations of reproductive pathology in BALB/c and C57BL/6 mice: fetal resorption (as a consequence of extreme T-cell activation obtained in the course of pretreatment), and lowering of fecundity (as a consequence of polyclonal B-cell stimu/lation), respectively. In BALB/c mice fetal resorption coincided with glycerol and CFA pretreatments, while in C57BL/6 mice lowering of fecundity was most obvious in CFA-A pretreated mice immunized with TTd in aluminum hydroxide. Both molecular mimicry and polyclonal B-cell activation occur in APS induction, with molecular mimicry effects being dominant in BALB/c mice, and polyclonal cell activation being dominant in C57BL/6 mice. Confirmation of molecular mimicry effects, which in the condition of T-cell stimulation generated fetal resorptions in the BALB/c strain, was achieved by passive infusion of monoclonal antibody (MoAb) T-26 specific for TTd and anti-β(2)-glycoprotein I obtained after TTd hyperimunization. High polyclonal B-cell activation in C57BL/6 mice prevented fetal resorption but induced fecundity lowering, as was the case in passive administration of MoAb T-26 in this mouse strain. Passive infusion of anti-idiotypic MoAb Y7 into C57BL/6 mice induced fetal resorptions and confirmed the above suggestion on the protective role of polyclonal B-cell stimulation in fetal resorptions.”


http://www.ncbi.nlm.nih.gov/pubmed/22235053 


“Experimental evidence also shows that simultaneous administration of as little as two to three immune adjuvants can overcome genetic resistance to autoimmunity. In some developed countries, by the time children are 4 to 6 years old, they will have received a total of 126 antigenic compounds along with high amounts of aluminum (Al) adjuvants through routine vaccinations. According to the US Food and Drug Administration, safety assessments for vaccines have often not included appropriate toxicity studies because vaccines have not been viewed as inherently toxic. Taken together, these observations raise plausible concerns about the overall safety of current childhood vaccination programs.” Lupus (2012) 21, 223–230

http://www.ncbi.nlm.nih.gov/pubmed/22235057


"These findings are consistent with the hypothesis that immunization with the recombinant hepatitis B vaccine is associated with an increased risk of MS, and challenge the idea that the relation between hepatitis B vaccination and risk of MS is well understood."

http://www.neurology.org/content/63/5/838.abstract


"Hepatitis B vaccination does not "generally" increase the risk of CNS inflammatory demyelination in childhood. However, the Engerix B vaccine appears to increase this risk, particularly for confirmed multiple sclerosis, in the longer term."

http://www.ncbi.nlm.nih.gov/pubmed/18843097


"Hepatitis B vaccine might be followed by various rheumatic conditions and might trigger the onset of underlying inflammatory or autoimmune rheumatic diseases."


http://www.ncbi.nlm.nih.gov/pubmed/10534549


Death after Quadrivalent Human Papillomavirus (HPV) Vaccination: Causal or Coincidental? “Our study suggests that HPV vaccines containing HPV-16L1 antigens pose an inherent risk for triggering potentially fatal autoimmune vasculopathies……It thus appears that in some cases vaccination may be the triggering factor of fatal autoimmune/neurological events. Physicians should be aware of this association."

Acquired autoimmunity syndromes occur after viral vaccinations. Molecular mimicry is involved in these phenomena as is the necessity for the presence of two chemically complimentary antigens and an immunologic adjuvant. The HLA pattern of the host is also an important factor. The example used to explain these phenomena is demyelinating disease that follows hepatitis B vaccination. The somatic antigen of the hepatitis B virus in the vaccine has chemical complimentarity with the Epstein-Barr virus antigen in the vaccine recipient. The Epstein-Barr virus shows molecular mimicry with human myelin. The immunologic adjuvant is either present in the vaccine or muramyl peptides in the individual who is vaccinated. Why more than one type of autoimmune disease occurs is explained by the fact that specific autoimmune T-cells have been shown to develop clones that attack multiple human tissues.”

http://www.ncbi.nlm.nih.gov/pubmed/17630224  

A role for the body burden of aluminium in vaccine-associated macrophagic myofasciitis and chronic fatigue syndrome
"Herein, we have described a case of vaccine-associated chronic fatigue syndrome and macrophagic myofasciitis in an individual demonstrating aluminium overload. This is the first report linking the latter with either of these two conditions and the possibility is considered that the coincident aluminium overload contributed significantly to the severity of these conditions in this individual. This case has highlighted potential dangers associated with aluminium-containing adjuvants and we have elucidated a possible mechanism whereby vaccination involving aluminium-containing adjuvants could trigger the cascade of immunological events which are associated with autoimmune conditions including chronic fatigue syndrome and macrophagic myofasciitis."


http://www.ncbi.nlm.nih.gov/pubmed/19004564

"Although the exact pathogenesis of the development of KFD following immunization remains unknown, this (IMMUNIZATION) should be added to the list of potential triggers or factors associated with the development of KFD"

http://www.ncbi.nlm.nih.gov/pubmed/22476507

 

 

Vaccines take time to do damage.

 

 


"Although there is no information regarding the duration of acceptable observation period, 1–3 months may not be long enough for the purpose, considering that it takes 2–6 months for adjuvant oils to induce lupus autoantibodies in mice [8,9,34] and that the oil-induced granulomatous inflammation can last for years."


"An important factor to consider in vaccine-induced autoimmunity is the fact that vaccines contain a microbial component (or other type of antigens) and adjuvant [75]. Differentiating adverse reactions caused by these two factors is often difficult, or it can even be a result of the combination of both. Nevertheless, the microbial components are generally considered responsible for adverse reactions and minimum attention has been paid to the potential effects of the adjuvant component. Molecular mimicry of a microbial antigen in a vaccine and a host tissue self-antigen is often considered important [61]. Immune complexes also may be formed following vaccination [61,76], deposit in vascular endothelium and induce vasculitis. Induction of cytokines or shifting cytokine balance may also play an important role."


http://www.ncbi.nlm.nih.gov/pubmed/15194169

 

"Clustering of cases of insulin dependent diabetes (IDDM) occurring three years after hemophilus influenza B (HiB) immunization support causal relationship between immunization and IDDM (insulin depedent diabetes)."

http://www.ncbi.nlm.nih.gov/pubmed/12911277


'Xenotropic murine leukemia virus-related virus (XMRV) is a recently discovered human retrovirus that has been found in both chronic fatigue syndrome & prostate cancer patients. There is a potential safety concern regarding XMRV in cell substrates used in vaccines...'

 

http://www.fda.gov/biologicsbloodvaccines/scienceresearch/biologicsresearchareas/ucm127327.htm

Vaccines can NOT guarantee immunity. It is ONLY a hope.

 


"Although persons often use vaccination and immunization interchangeably in reference to active immunization (VACCINES), the terms are not synonomous because the administration of an immunobiologic cannot be automatically equated with the development of adequate immunity."


http://www.cdc.gov/mmwr/PDF/rr/rr4301.pdf


 

Vaccines viruses shed to immuno-compromised children, pregnant women & the elderly.


This is a real risk no one ever thinks matters. Those vaccine viruses are just as contagious as a wild type viruses in the vaccinated.  No matter what they say, those vaccine viruses shed to immunocompromised children pregnant mothers and the elderly. And youre sitting their saying please get your children vaccinated and shed to my immunocompromised child! It’s a no brainer. Shedding viruses cause disease too! This is not just true for live virus vaccines, because the FDA has admitted to unintented "latent, quiet viruses that may become active after vaccine manufacturing"



 

VACCINES SPREAD DISEASE
 

“Baboons vaccinated with aP (pertussis vaccine) were protected from severe pertussis-associated symptoms (NOT TRUE) but not from colonization (infection), DID NOT clear the infection faster than naïve (unvaccinated) animals, and READILY transmitted B. pertussis to unvaccinated contacts.” 2013
 

http://www.ncbi.nlm.nih.gov/pubmed/24277828  or
 

http://www.accessdata.fda.gov/scripts/publications/search_result_record.cfm?id=48636

 

"A 12-month-old healthy boy had approximately 30 vesicular skin lesions 24 days after receiving varicella vaccine. Sixteen days later his pregnant mother had 100 lesions. Varicella-vaccine virus was identified by ...polymerase chain reaction in the vesicular lesions of the mother. After an elective abortion, no virus was detected in the fetal tissue. This case documents transmission of varicella-vaccine virus from a healthy 12-month-old infant to his pregnant mother."

 

http://www.ncbi.nlm.nih.gov/pubmed/9255208

 

"Twelve days after receiving an investigational Oka strain live attenuated varicella vaccine, a 38-year-old healthy white woman developed a rash consisting of 30 scattered lesions. Sixteen days later, her 2 children also developed rash. Swabs obtained from the skin lesions of the vaccinee and her children demonstrated the presence of varicella-zoster virus (VZV) DNA by a polymerase chain reaction (PCR) assay. Restriction endonuclease polymorphisms present in wild and vaccine type VZV were examined, and the amplified VZV DNA was determined to be vaccine type. This case documents transmission of varicella vaccine type virus from a healthy vaccinee to susceptible household contacts. Since vaccine-associated rashes are uncommon and mild, it is likely that transmission of vaccine virus will also be uncommon. With widespread immunization beginning in the United States, ongoing studies will define the frequency of this transmission."
http://www.ncbi.nlm.nih.gov/pubmed/9333170

 

"Excretion of small amounts of the live attenuated rubella virus from the nose or throat has occurred in the majority of susceptible individuals 7 to 28 days after vaccination." CONGENITAL RUBELLA SYNDROME ANYONE???

 

http://www.merck.com/product/usa/pi_circulars/m/mmr_ii/mmr_ii_pi.pdf

 

“Our unvaccinated and under-vaccinated population did not appear to contribute significantly to the increased rate of clinical pertussis. Surprisingly, the highest incidence of disease was among previously vaccinated children in the eight to twelve year age group.”

 

http://www.ncbi.nlm.nih.gov/pubmed/22423127

 

Witt M et al. 2012. Unexpectedly Limited Durability of Immunity Following Acellular Pertussis Vaccination in Pre-Adolescents in a North American Outbreak. Clin Infect Dis. Clin Infect Dis. 2012 Jun;54(12):1730-5. PMID:22423127

 

 

“An acellular whooping cough vaccine actually enhances the colonization of Bordetella parapertussis in mice; pointing towards a rise in B. parapertussis incidence resulting from acellular vaccination, which may have contributed to the observed increase in whooping cough over the last decade”.- Penn State

 

http://www.cidd.psu.edu/research/synopses/acellular-vaccine-enhancement-b.-parapertussis

 

 

Anne Schuchat, MD, the director for the National Center for Immunization and Respiratory Disease of the CDC says parents who opt out of vaccination for Pertussis are NOT TO BLAME for Whopping Cough outbreaks.

 "We know there are places around the country where there are large numbers of people who aren't vaccinated. However, we don't think those exemptors are driving this current wave. We think it is a bad thing that people aren't getting vaccinated or exempting, but we cannot blame this wave on that phenomenon. Next question. "

 

http://www.cdc.gov/media/releases/2012/t0719_pertussis_epidemic.html

 

 

"Vaccine-type rotavirus was detected in all 50 antigen-positive specimens and 8 of 8 antigen-negative specimens. Nine (75%) of 12 EIA-positive and 1 EIA-negative samples tested culture-positive for vaccine-type rotavirus. Fecal shedding of rotavirus vaccine virus after the first dose of RV5 occurred over a wide range of post-vaccination days not previously studied."

 

http://www.ncbi.nlm.nih.gov/pubmed/21477676

 

“During July 2005, the infant had multiple medical visits for respiratory illness and was hospitalized at a community hospital (hospital 1) for bronchiolitis and bacterial conjunctivitis. During August, she had medical visits for failure to thrive, fever, diarrhea, and anemia. Beginning 22 August 2005, she was hospitalized continuously at a regional medical center(hospital2),a children’s hospital (hospital 3), and a university hospital (hospital 4) for fever, irritability, bloody diarrhea, and recurrent infections. She never had paralysis. A stool specimen, obtained on 27 August 2005 on admission to hospital 3, was positive for an enterovirus that was ultimately confirmed to be a VACCINE DERIVED POLIO VIRUS by the Minnesota Department of Health Public Health Laboratory on 29 September 2005.”

 

http://www.ncbi.nlm.nih.gov/pubmed/19090774

 

"A 44-year-old woman with long-standing common variable immunodeficiency who was receiving intravenous immune globulin suddenly had paralysis of all four limbs and the respiratory muscles, resulting in death. Type 2 VACCINE-derived poliovirus was isolated from stool."

 

http://www.nejm.org/doi/full/10.1056/NEJMoa1008677 (New England Journal of Medicine)

 

 

Persistence of vaccine-derived polio viruses among immunodeficient persons with vaccine-associated paralytic poliomyelitis.Patient 1 was a 17-month-old girl. She had exhibited antibody deficiency and thus received inactivated polio vaccine (IPV). She was a household contact of a healthy OPV-vaccinated sibling. Limited data indicated that paralysis became evident in June 1995. All 3 fecal specimens collected 3–6 days after onset of paralysis yielded VACCINE-DERIVED POLIO VIRUS type 2. Recombination with the Sabin 1 strain was detected, with a crossover site at nt 5355 (3A). The girl died 8 days after onset of paralysis with obscured etiology.

 

Patient 2 was a boy born in January 2005. He received 4 doses of OPV, administered at birth and at 2, 4, and 6 months of age. In August 2005, he was hospitalized with irritability, drowsiness, hypotonia, and right paraparesis. Two collected fecal specimens tested were positive for VACCINE-DERIVED POLIO VIRUS type 2. Recombination with the Sabin 1 strain was also found at nt 5358. At baseline, he had mild anemia, hypogammaglobulinemia, and diminished CD4+ T-cell counts. A test result for HIV was negative. The expression of human leukocyte antigen DR on his lymphocytes was low, indicating major histocompatibility complex class II deficiency. His condition deteriorated during the next several months, with involvement of respiratory muscles and 3 episodes of aspiration pneumonia. He died of respiratory failure at 11 months of age. Follow-up fecal cultures during his illness showed persistent VACCINE-DERIVED POLIO VIRUS type 2 shedding.

 

Patient 3 was a boy born in January 2006. Beginning at 2 months of age, he had chronic diarrhea, malabsorption, and failure to thrive. Recurrent episodes of pneumonia also developed, beginning when the boy was 4 months of age. OPV was administered at birth and at 2, 4, and 6 months of age. In October 2006, he was referred to hospital showing symptoms of acute paralysis of the left leg of 2 weeks’ duration, followed by involvement of his right leg and upper arms, accompanied by drowsiness, fever, and hypotonia. Laboratory results showed lymphopenia; anemia; decreased levels of immunoglobulin (Ig) G, IgA, and IgM; and diminished CD3+, CD4+, and CD8+ T-cell counts (Table 2). VACCINE-DERIVED POLIO VIRUS type 2 was isolated from both of his collected fecal specimens. The final diagnosis was severe combined immunodeficiency (SCID) caused by RAG2 mutation (R229W) (N. Parvaneh, unpub. data). The boy died <3 months after onset of paralysis after gram-negative sepsis in January 2007.

 

 

Patient 4 was a 15-month-old boy who had fever and weakness of the lower limbs in December 2006. He received 4 doses of OPV, administered at birth and at 2, 4, and 6 months of age. At admission to the hospital, his right leg was completely flaccid, and the left was paretic. VACCINE-DERIVED POLIO VIRUS type 3 was isolated from his feces. Recombination with the Sabin 1 strain was detected at the 3Dpol region of the genome. Immunologic workup showed hypogammaglobulinemia and diminished CD19+ B lymphocytes. The final diagnosis was X-linked agammaglobulinemia. The patient was treated with intravenous Ig and physical therapy. Follow-up fecal cultures showed no virus. He died 11 months after onset of paralysis with chronic respiratory insufficiency (12,13).

 

Patient 5, a girl born in September 2006, was the third child of healthy parents. She received OPV at birth and in November 2006. In February 2007, she was hospitalized with severe pneumonia and paraparesis. Two fecal specimens collected on days 3 and 5 after onset of paralysis were positive for VACCINE-DERIVED POLIO VIRUS types 1 and 2. B cell–negative T cell–negative SCID was diagnosed (Table 2); the girl died of severe sepsis and multiple organ failure in April 2007, 1 month after onset of VAPP.

 

Patient 6, a boy 2 years of age, had weakness in his right leg. At 7 months of age, progressive paralysis of the extremity developed after a febrile illness. His first fecal specimen was positive for the Sabin 2 strain. He subsequently experienced several episodes of pneumonia and upper respiratory infections necessitating hospitalization. Immunologic workup favored a diagnosis of X-linked agammaglobulinemia (Table 2). Electrodiagnostic studies of the affected limb indicated femoral nerve mononeuropathy. One of 2 additional fecal specimens collected was positive for VACCINE-DERIVED POLIO VIRUS type 2. The boy began intravenous Ig substitution (600 mg/kg every 4 weeks, continuing to date). Follow-up fecal samples became negative for polioviruses. His immunodeficiency is under control, and he has only residual paralysis of the right leg.

 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321898/

OR

http://wwwnc.cdc.gov/eid/article/16/7/09-1606_article.htm ACCESSED JULY 2013

 

“The FluMist influenza vaccine strains replicate in the nasopharynx and can be recovered and cultured from respiratory secretions of vaccinated individuals (shed). The pattern and duration of shedding is important to understand because with prolonged shedding at high titer there is a theoretical risk of loss of attenuated phenotype, reassortment with wild-type influenza virus during influenza season, and transmission of vaccine virus to unvaccinated people, some of whom may be immunocompromised and/or at risk for complications of live viral infections. “

“additional shedding samples collected every 7 days ... though some individuals shed vaccine strain virus as late as day 28”
 

www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM259175.pdf

 

The RotaTeq vaccine contains five live, attenuated strains derived through laboratory reassortment of human rotavirus strains with a bovine rotavirus strain [3,4]. Three RotaTeq strains (WI78-8, BrB-9 and WI79-4) each contain a single human rotavirus gene segment and ten bovine rotavirus segments, and two strains (WI79-9 and SC2-9) contain two human strain segments and nine bovine strain segments. In the study, RotaTeq was detected in 16 stool samples. Ten of these contained between one and four individual vaccine component strains. Six samples were found to contain a vaccine-derived G1P[8] (vdG1P[8]) strain. vdG1P[8] is believed to be the product of a genetic reassortment event in which the G1 gene segment of strain WI79-9 is inserted into strain WI79-4, as evidenced by the association of G1-VP7 and P[8]-VP4 human rotavirus genes with the M2-VP3 and I2-VP6 of the bovine rotavirus. Donato et al. observed that approximately a fifth of the infants having diarrhea {DUH aka ROTAVIRUS} within 2 weeks of rotavirus vaccination were shedding vaccine strain components exclusive of any detectable enteric pathogen.”

 

http://www.ncbi.nlm.nih.gov/pubmed/23249230 FULL TEXT http://www.expert-reviews.com/doi/full/10.1586/erv.12.114

 

 

"Analysis of 36 individuals over age 60 years who were immunized with Zostavax revealed varicella zoster virus DNA in swabs of skin inoculation sites obtained immediately after immunization in 18 (50%) of 36 subjects and in saliva collected over 28 days in 21 (58%) of 36 subjects. Genotypic analysis of DNA extracted from 9 random saliva samples identified vaccine virus in ALL instances. In some immunized individuals over age 60, vaccine virus DNA is shed in saliva up to 4 weeks." "Zostavax contains live attenuated VZV, and the package insert warns newly vaccinated individuals to avoid contact for an unspecified time with newborn infants, immunosuppressed individuals, and pregnant women who have not had chicken pox or have not been immunized for chicken pox. Because VZV DNA is present in saliva of zoster patients for at least 2 weeks [5] and VZV in saliva can also be infectious [6], we examined the inoculation site and saliva of Zostavax-vaccinated subjects for the presence of VZV DNA for 4 weeks after immunization"

 

FULL TEXT http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096786/

 

“Type 1 vaccine-derived poliovirus (VDPV) was identified in September 2005, from an unvaccinated Amish infant hospitalized in Minnesota with severe combined immunodeficiency. An investigation was conducted to determine the source of the virus and its means of transmission.”

 

http://www.ncbi.nlm.nih.gov/pubmed/19090774

 

“All of the OPV-like isolates and the 'suspected' iVDPVs carried mutations at specific positions in their partially sequenced regions, which have been associated with reversion of the attenuated Sabin PV vaccine strains to INCREASED neurovirulence.” CONCLUSIONS: Thus, this study adds further evidence to the observation that immunodeficient individuals may excrete OPV strains with potential neurovirulent phenotypes.”

 

"Prolonged excretion of Polio Viruses by immunodeficient individuals is of major concern, because continued replication of Polio Viruses in the human gut could result in the reversion of these viruses to GREATER NEUROVIRULENCE. When exposed to OPV, immunodeficient patients may become chronically infected, spreading potentially neurovirulent Vaccine Derived Polio Viruses for many months or years to close contacts and children who are no longer being vaccinated after termination of OPV vaccination in the near future."

 

http://www.ncbi.nlm.nih.gov/pubmed/17105568

 

“the Vaccine Derived Polio Virus was found in an area where conditions favor Vaccine Derived Polio Virus emergence and spread.”

http://www.ncbi.nlm.nih.gov/pubmed/17449127

 

"OBJECTIVES: To evaluate the threat of vaccine-derived poliovirus (1-15% divergence from the respective Sabin strain) for a poliomyelitis-free population in a country with a long-standing routine vaccination program.

CONCLUSIONS: Our findings, which show that OPV is excreted for a significant period by children with high humoral immunity, emphasize the long-term potential threat from Vaccine Derived Polio Virus in highly vaccinated populations. "

 

http://www.ncbi.nlm.nih.gov/pubmed/16805227

 

 

ALL Vaccines are contaminated.

 

The question is contaiminated with WHAT? There are other unintended viruses that arent detected or tested for from the transmission of animal and human cell lines used in manufacturing vaccines (and those viruses can be shedding too). ​


• Investigations of porcine circovirus type 1 (PCV1) in vaccine-related and other cell lines. “Porcine circovirus type 1 (PCV1) is highly prevalent in swine and was recently reported in some rotavirus vaccines.” 011 Oct 26;29(46):8429-37. Epub 2011 Aug 9.

http://www.ncbi.nlm.nih.gov/pubmed/21835219?dopt=Abstract


• ABORTED FETAL CELL LINES- "In some cases the cell lines that are used might be tumorigenic, that is, they form tumors when injected into rodents. Some of these tumor-forming cell lines may contain cancer-causing viruses that are not actively reproducing. Such viruses are hard to detect using standard methods. These latent, or "quiet," viruses pose a potential threat, since they might become active under vaccine manufacturing conditions.”

WOULD YOU RISK THIS ON YOUR CHILD????!!! Well, I am NOT.


 http://www.fda.gov/biologicsbloodvaccines/scienceresearch/biologicsresearchareas/ucm127327.htm


• 'Xenotropic murine leukemia virus-related virus (XMRV) is a recently discovered human retrovirus that has been found in both chronic fatigue syndrome & prostate cancer patients. There is a potential safety concern regarding XMRV in cell substrates used in vaccines...'

 

http://www.fda.gov/biologicsbloodvaccines/scienceresearch/biologicsresearchareas/ucm127327.htm

“vaccines are not standard from one batch to the next. 3. Unless the vaccine is properly prepared and refrigerated, its potency and reactivity varies with shelf life. In fact, the whole question of vaccine detoxification has never been systematically investigated. Listed in order of increasing severity, observed adverse reactions include irritability, persistent, unusually high pitched crying, somnolence, seizures, a shock-like "hypotensive, hyporesponsive" state, and an encephalopathy. Since the neurologic picture is not specific for pertussis vaccination, its temporal relationship to the vaccination is the critical variable for determining causation. “


http://www.ncbi.nlm.nih.gov/pubmed/1981251

“ However, since vaccine preparation involves the use of materials of biological origin, vaccines are subject to contamination by micro-organisms. In fact, vaccine contamination has occurred; a historical example of vaccine contamination, for example, can be found in the early days of development of the smallpox vaccine. The introduction of new techniques of vaccine virus production on cell cultures has lead to safer vaccines, but has not completely removed the risk of virus contamination. There are several examples of vaccine contamination, for example, contamination of human vaccines against poliomyelitis by SV40 virus from the use of monkey primary renal cells. Several veterinary vaccines have been contaminated by pestiviruses from foetal calf serum.These incidents have lead industry to change certain practices and regulatory authorities to develop more stringent and detailed requirements. But the increasing number of target species for vaccines, the diversity of the origin of biological materials and the extremely high number of known and unknown viruses and their constant evolution represent a challenge to vaccine producers and regulatory authorities.”
 

http://www.ncbi.nlm.nih.gov/pubmed/20456974

 

“We examined live virus vaccines against measles, mumps, and rubella for the presence of pestivirus RNA or of pestiviruses by reverse transcription PCR. Pestivirus RNA was detected in two measles-mumps-rubella combined vaccines and in two monovalent vaccines against mumps and rubella. Nucleotide sequence analysis of the PCR products indicated that a modified live vaccine strain used for immunization of cattle against bovine viral diarrhea is not responsible for the contamination of the vaccines.” (something else inside them is...)
 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC264050/
 

“The novel human retrovirus xenotropic murine leukemia virus-related virus (XMRV) is arguably the most controversial virus of this moment. After its original discovery in prostate cancer tissue from North American patients, it was subsequently detected in individuals with chronic fatigue syndrome from the same continent. However, most other research groups, mainly from Europe, reported negative results. The positive results could possibly be attributed to contamination with mouse products in a number of cases, as XMRV is nearly identical in nucleotide sequence to endogenous retroviruses in the mouse genome. But the detection of integrated XMRV proviruses in prostate cancer tissue proves it to be a genuine virus that replicates in human cells, leaving the question: how did XMRV enter the human population? We will discuss two possible routes: either via direct virus transmission from mouse to human, as repeatedly seen for, e.g., Hantaviruses, or via the use of mouse-related products by humans, including vaccines. We hypothesize that mouse cells or human cell lines used for vaccine production could have been contaminated with a replicating variant of the XMRV precursors encoded by the mouse genome.”
 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109487/
 

“This overview describes the problems and risks associated with viral contaminations in animal cell culture, describes the origins of these contaminations as well as the most important viruses associated with viral contaminations in cell culture.” (cell cultures used in vaccines)

“contaminations are a serious threat for animal cell cultures and may lead to false results in research, development, and virus screening, to viral contaminations in the biologicals derived from the contaminated cultures and finally to an infection of the treated patient.”

 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463984/

 

“Current U.S. requirements for testing cell substrates used in production of human biological products (*VACCINES*) for contamination with bovine and porcine viruses are U.S. Department of Agriculture (USDA) 9CFR tests for bovine serum or porcine trypsin. 9CFR requires testing of bovine serum for seven specific viruses in six families (immunofluorescence) and at least 2 additional families non-specifically (cytopathicity and hemadsorption). 9CFR testing of porcine trypsin is for porcine parvovirus. Recent contaminations suggest these tests may not be sufficient. Assay sensitivity was not the issue for these contaminations that were caused by viruses/virus families not represented in the 9CFR screen. A detailed literature search was undertaken to determine which viruses that infect cattle or swine or bovine or porcine cells in culture also have human host range [ability to infect humans or human cells in culture] and to predict their detection by the currently used 9CFR procedures. There are more viruses of potential risk to biological products manufactured using bovine or porcine raw materials than are likely to be detected by 9CFR testing procedures; even within families, not all members would necessarily be detected....
 

Cell-culture derived vaccines for human use were developed in the 1950’s. Since fetal calf serum and bovine or porcine trypsin were used in cell culture, the 9CFR tests developed for veterinary use to screen for viruses that can infect cattle and swine were implemented by the authorities regulating human vaccines. However, many viruses not of significant concern to the cattle and swine industry are not addressed by the 9CFR testing. Today, over half a century after cell culture-derived vaccines were initially developed, the human biologics industry is still using the methods specified in the 9CFR regulations for testing FBS and porcine trypsin.”
 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206158/

 

 

{Remember SV 40 is found in cancer patients}
"Mycoplasmas in frozen bovine serum were effectively inactivated by gamma-irradiation at 25-40 kGy. The larger viruses tested, respiratory enteric orphan (REO) and Cache Valley virus (CVV), were inactivated completely, while the smaller virus, simian virus type 40, was not inactivated. Gamma-irradiation of bovine-sourced serum is therefore useful for mitigating the risk of introduction of mycoplasmas and many of the viral contaminants found in biologics unprocessed bulk (e.g., CVV, REO virus, epizootic hemorrhagic disease virus). This mitigation strategy is not useful for the smaller viruses (e.g., polyomaviruses, parvoviruses, picornaviruses, caliciviruses)." 2010

 

http://www.ncbi.nlm.nih.gov/pubmed/21502047

 

"All currently licensed yellow fever (YF) vaccines are propagated in chicken embryos. Recent studies of chick cell-derived measles and mumps vaccines show evidence of two types of retrovirus particles, the endogenous avian retrovirus (EAV) and the endogenous avian leukosis virus (ALV-E), which originate from the chicken embryonic fibroblast substrates. In this study, we investigated substrate-derived avian retrovirus contamination in YF vaccines currently produced by three manufacturers (YF-vax [Connaught Laboratories], Stamaril [Aventis], and YF-FIOCRUZ [FIOCRUZ-Bio-Manguinhos]). Testing for reverse transcriptase (RT) activity was not possible because of assay inhibition. However, Western blot analysis of virus pellets with anti-ALV RT antiserum detected three distinct RT proteins in all vaccines, indicating that more than one source is responsible for the RTs present in the vaccines."

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC140796/

 

 

“ Additionally, a baboon endogenous virus strain M7 was detected, likely due to the monkey cell line in which RotaTeq was produced from.”

 

“ The sample of RotaTeq vaccine tested positive for rotavirus A and baboon endogenous virus, as previously reported by Victoria and colleagues [17]. The origin of the baboon endogenous virus is assumed to be related to the African green monkey-derived Vero cell line used in its manufacture and cross-hybridization of its endogenous retroviruses to the baboon endogenous retrovirus probes [17].

 

Microarray analysis did not detect PCV from the RotaTeq vaccine, which confirmed the previous results from Victoria et al. that LLMDA detected PCV from Rotarix but did not detect PCV from the RotaTeq vaccine [17]. However, PCV2 in RotaTeq vaccine was detected by PCR assays. RotaTeq contained small PCV-1 and PCV-2 genome fragments but did not contain detectable larger portions of PCV genomes [30]. Studies have shown that the amount of PCV in RotaTeq was about 4000 times lower than the PCV in Rotarix, with the PCV in RotaTeq being barely detectable [25, 31, 32]. A case study by Ranucci et al. has reported that the concentration of PCV-2 DNA fragment in clinical consistency lots was in the range of below limit of detection to 6.4 × 103 copies/mL when measured by QPCR, and that PCV1 was below limit of detection (0.1–0.8 × 103 copies/mL) [30]. ” 2014

 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980782/

 

 

Our findings indicate that vaccinal immunity might facilitate an evolutional event through antigenic selection,

 

genetic mutation among virulent virus populations shed from vaccinated flocks,

 

or both.”

http://www.ncbi.nlm.nih.gov/pubmed/24689191

 

 

 

 

Jessica Ploughe

Vaccine Facts backed by Science